NMR Facility

Department of Chemistry University of Oxford

Oxygenase Catalysed Ribosome Hydroxylation Occurs in Prokaryotes and Humans
Wei Ge, Alexander Wolf, Tianshu Feng, Chia-hua Ho, Rok Sekirnik, Adam Zayer, Nicolas Granatino, Matthew E. Cockman, Christoph Loenarz, Nikita D. Loik, Adam P. Hardy, Timothy D.W. Claridge, Refaat B. Hamed, Rasheduzzaman Chowdhury, Lingzhi Gong, Carol V. Robinson, David C. Trudgian, Miao Jiang, Mukram M. Mackeen, James S. Mccullagh, Yuliya Gordiyenko, Armin Thalhammer, Atsushi Yamamoto, Ming Yang, Phebee Liu-Yi, Zhihong Zhang, Marion Schmidt-Zachmann, Benedikt M. Kessler, Peter J. Ratcliffe, Gail M. Preston, Mathew L. Coleman, Christopher J. Schofield.
Nature Chem. Biol., 2012, 8, 960-962.

Conformational analysis of fluorinated pyrrolidines using 19F-1H scalar couplings and heteronuclear nOes
Lorraine E. Combettes, Philip Clausen-Thue, Mike King, Barbara Odell, Amber L. Thompson, Véronique Gouverneur, and Tim D. W. Claridge.
Chem. Eur. J, 2012, 18, 13133-13141.

Synthesis of 3-Fluoropyrrolidines and 4-Fluoropyrrolidin-2-ones from Allylic Fluorides
Lorraine E. Combettes, Marie Schuler, Rakesh Patel, Baltasar Bonillo, Barbara Odell, Amber L. Thompson, Tim D. W. Claridge, and Véronique Gouverneur.
Chem. Eur. J, 2012, 18, 13126-13132.

Ammonium-Directed Olefinic Epoxidation: Kinetic and Mechanistic Insights
Méabh B. Brennan, Timothy D. W. Claridge, Richard G. Compton, Stephen G. Davies, Ai M. Fletcher, Martin C. Henstridge, David S. Hewings, Wataru Kurosawa, James A. Lee, Paul M. Roberts, Anne K. Schoonen, and James E. Thomson.
J. Org. Chem, 2012, 77, 7241-7261.

γ-Butyrobetaine Hydroxylase Catalyses a Stevens Type Rearrangement
Luc Henry, Ivanhoe K. H. Leung, Timothy D. W. Claridge, Christopher J. Schofield.
Biorg. Med. Chem. Lett., 2012, 22, 4975-4978.

Development and application of a fluoride detection based fluorescence assay for γ-butyrobetaine hydroxylase
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Armin Thalhammer, Udo Oppermann, Timothy D. W. Claridge and Christopher J. Schofield.
ChemBioChem, 2012, 13, 1559–1563.

Fluorescent Charge-Assisted Halogen-Bonding Macrocyclic Halo-Imidazolium Receptors for Anion Recognition and Sensing in Aqueous Media
Fabiola Zapata, Antonio Caballero, Nicholas G. White, Tim D. W. Claridge, Paulo J. Costa, Vitor Felix and Paul D. Beer.
J. Am. Chem. Soc., 2012, 134, 11533-11541.

Sterically Encumbered Iridium Bis(N-heterocyclic carbene) Complexes: Air-Stable 14-Electron Cations and Facile Degenerate C-H Activation
Phillips, Nicholas; Rowles, Johnny; Kelly, Michael J.; Riddlestone, Ian; Rees, Nicholas H.; Dervisi, Athanasia; Fallis, Ian A.; Aldridge, Simon
Organometallics, 2012, 31, 8075-8078.

Dynamic Chemistry Employing Boronic Acids / Boronate Esters Leads to Potent Oxygenase Inhibitors
Marina Demetriades, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Mun Chiang Chan,  Kar Kheng Yeoh,Ya-Min Tian, Timothy D.W Claridge, Peter J. Ratcliffe, Esther C. Y. Woon,  Christopher J. Schofield.
Angew. Chem. Int. Ed. Engl., 2012, 51, 6672-6675.  

Observation of a Transient Intermediate in Soai's Asymmetric Autocatalysis: Insights from 1H NMR Turnover in Real Time
Gehring, Timo; Quaranta, Michela; Odell, Barbara; Blackmond, Donna G.; Brown, John M.
Angew. Chem. Int. Ed. Engl., 2012, 51, 9539-9542

Conformational Effects in Sugar Ions: Spectroscopic Investigations in the Gas Phase and in Solution
Ram Sagar, Svemir Rudić,  David P. Gamblin, Eoin M. Scanlan, Timothy D. Vaden, Barbara Odell, Timothy D.W. Claridge, John P. Simons and Benjamin G. Davis
Chem. Sci., 2012, 3, 2307-2313

Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
Refaat B. Hamed, Luc Henry, J. Ruben Gomez-Castellanos, Jasmin Mecinović, Christian Ducho, John L. Sorensen, Timothy D. W. Claridge, and Christopher J. Schofield
J. Am. Chem. Soc., 2012, 134, 471-479