NMR Facility

Department of Chemistry University of Oxford

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.
Refaat B. Hamed, Luc Henry, J. Ruben Gomez-Castellanos, Amina Asghar, Jürgen Brem, Timothy D. W. Claridge  and Christopher J. Schofield
Org. Biomol. Chem., 2013, 11, 8191-8196.

Solution phase structures of enantiopure and racemic lithium N-benzyl-N-(α-methylbenzyl)amide in THF: low temperature 6Li and 15N NMR spectroscopic studies.
Timothy D. W. Claridge, Stephen G. Davies, Dennis Kruchinin, Barbara Odell, Paul M. Roberts, Angela J. Russell, James E. Thomson, Steven M. Toms.
Tetrahedron: Asymmetry, 2013, 24, 947–952.

A Discrete Three-Layer Stack Aggregate of a Linear Porphyrin Tetramer: Solution-Phase Structure Elucidation by NMR and X-Ray Scattering.
Marie Hutin, Johannes K. Sprafke, Barbara Odell, Harry L. Anderson and Tim D. W. Claridge.
J. Am. Chem. Soc., 2013, 135, 12798−12807.

Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Sander S. van Berkel, Joanne E. Nettleship, Ivanhoe K. H. Leung, Jürgen Brem, Hwanho Choi, David I. Stuart, Timothy D. W. Claridge, Michael A. McDonough, Raymond J. Owens, Jingshan Ren, Christopher J. Schofield.
ACS Chem. Biol., 2013, 8, 2112-2116.

Chiral Recognition in Contact Ion-pairs; Observation, Characterization and Analysis.
J. A. Raskatov, A. L. Thompson, A. R. Cowley, T. D. W. Claridge and J. M. Brown.
Chem. Sci., 2013, 4, 3140 – 3147.

Multielement NMR Studies of the Liquid-Liquid Phase Separation and the Metal-to-Nonmetal Transition in Fluid Lithium- and Sodium-Ammonia Solutions
Lodge, Matthew T. J. H.; Cullen, P.; Rees, Nicholas H.; Spencer, Neil; Maeda, Kiminori; Harmer, Jeffrey R.; Jones, Martin O.; Edwards, Peter P.
Journal of Physical Chemistry B 2013, 117, 13322-13334.

Local probes show that framework modification in zeolites occurs on ammonium exchange without calcination
Sartbaeva, Asel; Rees, Nicholas H.; Edwards, Peter P.; Ramirez-Cuesta, Anibal J.; Barney, Emma
Journal of Materials Chemistry A: Materials for Energy and Sustainability 2013, 1, 7415-7421.

Is JmjC Oxygenase Catalysis Limited to Demethylation?

Richard J. Hopkinson, Louise J. Walport, Martin Münzel, Nathan R. Rose, Tristan J. Smart, Akane Kawamura, Timothy D. W. Claridge and Christopher J. Schofield.
Angew. Chem. Int. Ed. Engl., 2013, 52, 7709-7713.

A phthalate family oxygenase reductase supports terpene alcohol oxidation by CYP238A1 from Pseudomonas putida KT2440
Bell, Stephen Graham; French, Laura; Rees, Nicholas Huw; Cheng, Sophia Shuyi; Preston, Gail; Wong, Luet-Lok
Biotechnology and Applied Biochemistry 2013, 60, 9-17.

Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor
Ming Yang, Adam P. Hardy, Rasheduzzaman Chowdhury, Nikita D. Loik, John S. Scotti, James S. O. McCullagh, Timothy D. W. Claridge, Michael A. McDonough, Wei Ge and Christopher J. Schofield.
Angew. Chem. Int. Ed. Engl., 2013,  52,1700-1704.

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors
Ivanhoe K. H. Leung, Marina Demetriades, Adam P. Hardy, Clarisse Lejeune, Tristan J. Smart, Andrea Szöllössi, Akane Kawamura, Christopher J. Schofield, Timothy D. W. Claridge.
J. Med. Chem., 2013, 56, 547-555.

Acceleration of the Eschenmoser coupling reaction by sonication: efficient synthesis of enaminones
Naga Durgarao Koduri, Bethany Hileman, Justin D. Cox, Halee Scott, Phuong Hoang, Alexa Robbins, Kyle Bowers, Lemma Tsebaot, Kun Miao, Maria Castaneda, Michael Coffin, Guan Wei, Tim D. W. Claridge, Kenneth P. Roberts and Syed Raziullah Hussaini.
RSC Adv., 2013, 3, 181-188.