NMR Facility

Department of Chemistry University of Oxford

Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications.
Anna M. Rydzik, Ivanhoe K. H. Leung, Armin Thalhammer, Grazyna T. Kochan, Timothy D. W. Claridge  and Christopher J. Schofield
Chem. Commun., 2014, 50, 1175-1177 [DOI: 10.1039/c3cc47581f]

Synthetic control of retinal photochemistry and photophysics in solution.
Giovanni Bassolino, Tina Sovdat, Matz Liebel, Christoph Schnedermann, Barbara Odell, Timothy D.W. Claridge, Philipp Kukura, Stephen P. Fletcher
J. Am. Chem. Soc., 2014, 136, 2650-2658. [DOI: 10.1021/ja4121814]

Monitoring conformational changes in the NDM-1 Metallo-β-lactamase by 19F NMR
Anna M. Rydzik, Jürgen Brem, Sander S. van Berkel, Inga Pfeffer, Anne Makena, Timothy D. W. Claridge, Christopher J. Schofield
Angew. Chem. Int. Ed. Engl., 2014, 53, 3129-3133. [DOI: 10.1002/anie.201310866]

Non-Enzymatic Chemistry Enables 2-Hydroxyglutarate Mediated Activation of 2-Oxoglutarate Oxygenases.
Hanna Tarhonskaya, Anna M. Rydzik, Ivanhoe K. H. Leung, Nikita D. Loik, Mun Chiang Chan, Akane Kawamura, James S. O. McCullagh, Timothy D. W. Claridge, Emily Flashman and Christopher J. Schofield
Nat. Commun., 2014, 5, 3423 [DOI:10.1038/ncomms4423]

Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases
Hanna Tarhonskaya, Andrea Szöllössi, Ivanhoe K. H. Leung, Jacob T. Bush, Luc Henry, Rasheduzzaman Chowdhury, Aman Iqbal, Timothy D. W. Claridge, Christopher J. Schofield, and Emily Flashman
Biochemistry, 2014, 53, 2483−2493. [DOI: 10.1021/bi500086p].

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Nikita D. Loik,  Luc Henry,  Michael A. McDonough,  Timothy D. W. Claridge and Christopher J. Schofield
Org. Biomol. Chem, 2014, 12, 6354–6358. [DOI: 10.1039/C4OB01167H]

Physical autocatalysis driven by a bond-forming thiol-ene reaction
Bissette, Andrew J., Odell, Barbara ;Fletcher, Stephen P.
Nature Communications (2014), 5, 4607

Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy
Gruber, Tobias; Thompson, Amber L.; Odell, Barbara;  Bombicz, Petra; Schofield, Christopher J.
New Journal of Chemistry (2014), 38(12), 5905-5917

Oxygenase-Catalysed Desymmetrisation of N,N-Dialkyl Piperidine-4-carboxylic acids.
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Michael A. McDonough, Timothy D. W. Claridge and Christopher J. Schofield
Angew. Chem. Int. Ed. 2014, 53, 10925 –10927 [DOI: 10.1002/anie.201406125]

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
John S. Scotti, Ivanhoe K. H. Leung, Wei Ge, Michael A. Bentley, Jordi Paps, Holger B. Kramer, Joongoo Lee, WeiShen Aik, Hwanho Choi, Steinar M. Paulsen, Lesley A. H. Bowman, Nikita D. Loik, Shoichiro Horita, Chia-hua Ho, Nadia J. Kershaw, Christoph M. Tang, Timothy D. W. Claridge, Gail M. Preston, Michael A. McDonough, and Christopher J. Schofield
Proc. Natl. Acad. Sci., 2014, 111, 13331-13336. [DOI:10.1073/pnas.1409916111].

A type-II biomarker for differentiating relapsing remitting from secondary progressive multiple sclerosis.
A.M. Dickens, J.R. Larkin, J. L. Griffin, A. Cavey, L. Matthews, M.R. Turner, G.K. Wilcock, B.G. Davis, T.D.W. Claridge, J. Palace, D.C. Anthony, N.R. Sibson
Neurology, 2014, 83, 1492-1499. [DOI: 10.1212/WNL.0000000000000905].

Rhodanine Hydrolysis Leads to Potent Thioenolate Mediated Metallo-β-Lactamase inhibition.
Jürgen Brem, Sander S. van Berkel, WeiShen Aik, Anna Rydzik, Matthew B. Avison, Ilaria Pettinati, Klaus-Daniel Umland, Akane Kawamura, James Spencer, Timothy D.W. Claridge, Michael A. McDonough, and Christopher J. Schofield
Nature Chem. 2014, 6, 1084-1090. [DOI:10.1038/nchem.2110]

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
Hanna Tarhonskaya, Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Nikita D. Loik, James S. O. McCullagh, Timothy D. W. Claridge, Christopher J. Schofield and Emily Flashman
Biochem. J., 2014, 463, 363–372. [DOI:10.1042/BJ20140779]

Toward the Understanding of Modulation in Molecular Materials: Barluenga's Reagent and its Analogues.
Kim, Yejin; Mckinley, Emma J.; Christensen, Kirsten E.; Rees, Nicholas H.; Thompson, Amber L
Crystal Growth & Design, 2014, 14, 6294-6301. [DOI: 10.1021/cg500983s]

Rationalizing and Disrupting Fluxional Processes in Agostically Stabilized 14-Electron Alkyliridium Hydride Complexes.
Phillips, Nicholas; Treasure, Lucinda; Rees, Nicholas H.; Tirfoin, Remi; McGrady, John E.; Aldridge, Simon
European Journal of Inorganic Chemistry, 2014, 28, 4877-4885 [DOI: 10.1002/ejic.201402516].