NMR Facility

Department of Chemistry University of Oxford

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1.
Jürgen Brem
, Weston B. Struwe, Anna M. Rydzik, Hanna Tarhonskaya, Inga Pfeffer, Emily Flashman, Sander S. van Berkel, James Spencer, Timothy D. W. Claridge, Michael A. McDonough, Justin L. P. Benesch and Christopher J. Schofield
Chemical Science, 2015, 6, 956-963. [DOI: 10.1039/C4SC01752H]

 Anomalous Nuclear Overhauser Effects in Carbon-Substituted Aziridines: Scalar Cross-Relaxation of the First Kind
Ilya Kuprov, David M. Hodgson, Johannes Kloesges, Christopher I. Pearson, Barbara Odell, and Timothy D. W. Claridge
Angew. Chem. Int. Ed. 2015, 54, 3697-3701. [DOI: 10.1002/anie.201410271]

Caterpillar Track Complexes in Template-Directed Synthesis and Correlated Molecular Motion
Shiqi Liu, Dmitry V. Kondratuk, Sophie A. L. Rousseaux, Guzmµn Gil-Ramírez, Melanie C. O’Sullivan, Jonathan Cremers, Tim D. W. Claridge, and Harry L. Anderson
Angew. Chem. Int. Ed. 2015, 54, 5355–5359 [DOI: 10.1002/anie.201412293]

Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients.
A. M. Dickens, D. C. Anthony, R. Deutsch, M. M. Mielke, T. D. W. Claridge, I. Grant, D. Franklin, D. Rosario, T. Marcotte,  S. Letendre, J. C.  McArthur, N. J.Haughey
AIDS, 2015, 29, 559-569 [DOI: 10.1097/QAD.0000000000000580].

Fluorophosphate Nucleotide Analogs as Versatile Tools for 19F NMR Studies
Marek R. Baranowski, Anna Nowicka, Anna M. Rydzik, Marcin Warminski, Renata Kasprzyk, Blazej A. Wojtczak, Jacek Wojcik, Timothy D. W. Claridge, Joanna Kowalska, Jacek Jemielity
J. Org. Chem., 2015, 80, 3982-3997. [DOI: 10.1021/acs.joc.5b00337]

Potent and Selective Triazole-based Inhibitors of the Hypoxia-inducible Factor Prolyl-hydroxylases with Activity in the Murine Brain.
Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M. Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D. W. Claridge, Akane Kawamura, Christopher W. Pugh, Peter J. Ratcliffe, Christopher J. Schofield
PLoS ONE 10(7): e0132004. [DOI:10.1371/journal.pone.0132004]

The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis
Elizabeth Gray, James R. Larkin, Tim D. W. Claridge, Kevin Talbot, Nicola R. Sibson, and Martin R. Turner
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2015, 1-8. [DOI:10.3109/21678421.2015.105349]

NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis.
Alex M. Dickens, James R. Larkin, Benjamin G. Davis, Julian L. Griffin, Timothy D. W. Claridge, Nicola R. Sibson, Daniel C. Anthony
J. Neuroimmune Pharmacol., 2015, 10, 435-444. [DOI: 10.1007/s11481-015-9622-0]

The Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor N-oxalylglycine is present in Rhubarb and Spinach Leaves.
Khalid Al-Qahtani, Bushra Jabeen, Rok Sekirnik, Naheed Riaz, Timothy D.W. Claridge, Christopher J. Schofield, James S.O. McCullagh
Phytochemistry, 2015, 117, 456-461. [DOI: 10.1016/j.phytochem.2015.06.028]

α- and α-LithiationElectrophile Trapping of N-Thiopivaloyl and N-tert-Butoxythiocarbonyl α-Substituted Azetidines: Rationalization of the Regiodivergence Using NMR and Computation.
Kelvin E. Jackson, Claire L. Mortimer, Barbara Odell, Jeffrey M. McKenna, Timothy D. W. Claridge, Robert S. Paton, and David M. Hodgson
J. Org. Chem., 2015, 80, 9838-9846. [DOI: 10.1021/acs.joc.5b01804]

Barrierless Photoisomerization of 11-cis Retinal Protonated Schiff Base in Solution
Giovanni Bassolino, Tina Sovdat, Alex Soares Duarte, Jong Min Lim, Christoph Schnedermann, Matz Liebel, Barbara Odell, Timothy D.W. Claridge, Stephen P. Fletcher, Philipp Kukura
J. Am. Chem. Soc., 2015, 137, 12434–12437. [DOI: 10.1021/jacs.5b06492].

Self-Assembly of Russian Doll Concentric Porphyrin Nanorings.
Sophie A. L. Rousseaux, Juliane Q. Gong, Rene!e Haver, Barbara Odell, Tim D. W. Claridge, Laura M. Herz, and Harry L. Anderson
J. Am. Chem. Soc., 2015, 137, 12713-12718. [DOI: 10.1021/jacs.5b07956].

Cation-π interactions contribute to substrate recognition in γ-butyrobetaine hydroxylase catalysis.
Jos J. A. G. Kamps, Amjad Khan, Hwanho Choi, Robert K. Lesniak, Jürgen Brem, Anna M. Rydzik, Michael A. McDonough, Christopher J. Schofield, Timothy D. W. Claridge and Jasmin Mecinović
Chem. Eur. J., 2015, 22, 1270-1276 [DOI: 10.1002/chem.201503761]

Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans.
Richard J. Hopkinson , Ivanhoe K. H. Leung, Tristan J. Smart, Nathan R. Rose, Luc Henry, Timothy D. W. Claridge, Christopher J. Schofield
PLoS ONE, 10(12):e0145085 [DOI: 10.1371/journal.pone.0145085]

H2 activation by a highly electron-deficient aralkylated organoborane
Hill, Peter J.; Herrington, Thomas J.; Rees, Nicholas H.; White, Andrew J. P.; Ashley, Andrew E.
Dalton Transactions, 2015, 44, 8984-8992 [DOI: 10.1039/C5DT00821B]

Stoichiometric and Catalytic Solid-Gas Reactivity of Rhodium Bis-phosphine Complexes
Pike, Sebastian D.; Kramer, Tobias; Rees, Nicholas H.; MacGregor, Stuart. A.; Weller, Andrew S.
Organometallics, 2015, 34, 1487-1497 [DOI: 10.1021/om5013133]

Solid-State Synthesis and Characterization of σ-Alkane Complexes, [Rh(L2)(η22-C7H12)][BArF4] (L2 = Bidentate Chelating Phosphine)
Pike, Sebastian D.; Chadwick, F. Mark; Rees, Nicholas H.; Scott, Mark P.; Weller, Andrew S.; Kramer, Tobias; Macgregor, Stuart A
Journal of the American Chemical Society, 137, 820-833 [DOI: 10.1021/ja510437p].