NMR Facility

Department of Chemistry University of Oxford

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.
Christopher T. Lohans, David Y. Wang, Christian Jorgensen, Samuel T. Cahill, Ian J. Clifton, Michael A. McDonough, Henry P. Oswin, James Spencer, Carmen Domene, Timothy D. W. Claridge, Jürgen Brem and Christopher J. Schofield.
Org. Biomol. Chem., 2017, 15, 6024-6032 [DOI: 10.1039/c7ob01514c]

Evaluation of 1H NMR metabolic profiling of Niemann Pick type 1 patient plasma as a potential diagnostic tool.
Fay Probert, Victor Ruiz-Rodado, Danielle te Vruchte, Elena-Raluca Nicoli, Tim D.W. Claridge, Christopher A. Wassif, Nicole Farhat, Forbes D. Porter, Frances M. Platt and Martin Grootveld.
Sci Reps. 2017, 7, 6320; [DOI: 10.1038/s41598-017-06264-2]

Mechanistic studies on a Cu-catalysed asymmetric allylic alkylation with cyclic racemic starting materials.
Emeline Rideau, Hengzhi You, Mireia Sidera, Timothy D. W. Claridge, Stephen P. Fletcher.
J. Am. Chem. Soc. 2017, 139, 5614−5624. [DOI: 10.1021/jacs.7b02440]

Monitoring the Disassembly of Virus-like Particles by 19F NMR.
Rogen L. C. Leung, Matthew D. M. Robinson, Alaa A. A. Ajabali, Gogulan Karunanithy, Brian Lyons, Ritu Raj, Saeed Raoufmoghaddam, Shabaz Mohammed, Timothy D. W. Claridge, Andrew J. Baldwin and Benjamin G. Davis.
J. Am. Chem. Soc. 2017, 139, 5277−5280. [DOI: 10.1021/jacs.6b11040]

19F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paolo Metallo-β-Lactamase.
Martine I. Abboud, Jürgen Brem, Philip Hinchliffe, Robert Macsics, Inga Pfeffer, Anne Makena, Klaus-Daniel Umland, Anna M. Rydzik, Guo-Bo Li, James Spencer, Timothy D.W. Claridge, and Christopher J. Schofield.
Angew. Chem. Int. Ed. 2017, 56, 3862 –3866. [DOI: 10.1002/anie.201612185]

Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.
Renjie Huang, Arnaud Bonnichon, Timothy D. W. Claridge, Ivanhoe K. H. Leung
Sci. Reps. 2017, 7, 43727; [DOI: 10.1038/srep43727]

Formation of a σ-alkane Complex and a Molecular Rearrangement in the Solid-State: [Rh(Cyp2PCH2CH2PCyp2)(η22-C7H12)][BArF4]
Alasdair I. McKay, Tobias Krämer, Nicholas H. Rees, Amber L. Thompson, Kirsten E. Christensen, Stuart A. Macgregor, and Andrew S. Weller
Organometallics, 2017, 36, 22–25. [DOI: 10.1021/acs.organomet.6b00645]

A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.
Omar Aldulaimi, Fidelia I. Uche, Hamza Hameed, Haddijatou Mbye, Imran Ullah, Falko Drijfhout, Timothy D.W. Claridge, Paul Horrocks, Wen-Wu Li
Journal of Ethnopharmacology, 2017, 198, 221–225. [DOI: 10.1016/j.jep.2017.01.014]

Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes.
Refaat B. Hamed, Luc Henry, Timothy D. W. Claridge, and Christopher J. Schofield
ACS Catalysis, 2017, 7, 1279−1285. [DOI: 10.1021/acscatal.6b02509]

Aromatic and antiaromatic ring currents in a molecular nanoring.
Martin D. Peeks, Timothy D. W. Claridge, Harry L. Anderson
Nature, 2017, 541, 200-203. [DOI: 10.1038/nature20798]