NMR Facility

Department of Chemistry University of Oxford

Studies on the Substrate Selectivity of the Hypoxia‐Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.
Martine I. Abboud, Rasheduzzaman Chowdhury, Ivanhoe K.H. Leung, Kerstin Lippl, Christoph Loenarz, Timothy D.W. Claridge, and Christopher J. Schofield, ChemBioChem, 2018, 19, 2262-2267  [DOI: 10.1002/cbic.201800246]

Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis.
Fay Probert, Alissa Walsh, Marta Jagielowicz, Tianrong Yeo, Timothy D. W. Claridge, Alison Simmons, Simon Travis, Daniel C Anthony, Journal of Crohn's and Colitis, 2018, 12, 1326–1337 [DOI: 10.1093/ecco-jcc/jjy101]

Human histone demethylase KDM6B can catalyse sequential oxidations.
Richard J. Hopkinson, Gareth W. Langley, Roman Belle, Louise J. Walport, Kate Dunne, Martin Münzel, Eidarus Salah, Akane Kawamura, Timothy D. W. Claridge and Christopher J. Schofield, Chem. Comm. 2018, 54, 7975-7978 [DOI: 10.1039/c8cc04057e]

The Dimroth rearrangement as a probable cause for structure mis-assignments in imidazo[1,2-a]pyrimidines: A 15N-labelling study and an easy method for the determination of regio-chemistry.
Maria Chatzopoulou, Fernando Martinez Vasquez, Nicky J. Willis, Timothy D. W. Claridge, Francis X. Wilson, Graham M. Wynne, Stephen G. Davies, Angela J. Russell, Tetrahedron, 2018, 38, 5280-5288 [DOI: 10.1016/j.tet.2018.06.033]

Molecular Structure from a Single NMR Supersequence.
Eriks Kupce and Tim D. W. Claridge, Chem. Comm., 2018, 54, 7139-7142 [DOI: 10.1039/C8CC03296C]

NMR Analyses on N-Hydroxymethylated Nucleobases – Implications for Formaldehyde Toxicity and Nucleic Acid Demethylases.
S. Shishodia, D. Zhang, A. El-Sagheer, T. Brown, T. D. W. Claridge, C. J. Schofield and R. J. Hopkinson, Org. Biomol. Chem. 2018,  16, 4021-4032 [DOI: 10.1039/c8ob00734a]

Non-competitive cyclic peptides for targeting enzyme-substrate complexes.
Tom E McAllister, Tzu-Lan Yeh, Martine I Abboud, Ivanhoe K H Leung, Edward S Hookway, Oliver N F King, Bhaskar Bhushan, Sophie T Williams, Richard J. Hopkinson, Martin Münzel, Nikita Loik, Rasheduzzaman Chowdhury, Udo Oppermann, Timothy D. W. Claridge, Yuki Goto, Hiroaki Suga, Christopher J. Schofield & Akane Kawamura, Chemical Science, 2018, 9, 4569-4578 [DOI: 10.1039/C8SC00286J]

NMReDATA, a standard to report the NMR assignment and parameters of organic compounds.
Marion Pupier, Jean-Marc Nuzillard, Julien Wist, Nils E. Schlörer, Stefan Kuhn, Mate Erdelyi, Christoph Steinbeck, Antony J. Williams, Craig Butts, Tim D. W. Claridge, Bozhana Mikhova, Wolfgang Robien, Hesam Dashti, Hamid R. Eghbalnia, Christophe Farès, Christian Adam, Kessler Pavel, Fabrice Moriaud, Mikhail Elyashberg, Dimitris Argyropoulos, Manuel Pérez, Patrick Giraudeau, Roberto R. Gil, Paul Trevorrow, Damien Jeannerat, Magn. Reson. Chem., 2018, , 56, 703-715 [DOI: 10.1002/mrc.4737]

Synthesis of statistical PET/PEN random block copolymers and their crystallizability in the bulk and at the surface.
Kei Shinotsuka,  Hazel Assender, and Timothy D. W. Claridge Journal of Applied Polymer Science, 2018, 135, 46515 [DOI: 10.1002/app.46515]

Measuring Spin Relaxation Rates using Satellite Exchange NMR Spectroscopy.
Gerard P. Robertson, Barbara Odell, Ilya Kuprov, Darren J. Dixon, and Tim D. W. Claridge, Angew. Chem. Int. Ed., 2018, ,  57, 7498-7502 [DOI: 10.1002/anie.201801322]

Template-Directed Synthesis of a Conjugated Zinc Porphyrin Nanoball.
Jonathan Cremers, Renee Haver, Michel Rickhaus, Juliane Q. Gong, Ludovic Favereau, Martin D. Peeks, Tim D. W. Claridge, Laura M. Herz, and Harry L. Anderson, J. Am. Chem. Soc., 2018, 140, 5352-5355. [DOI: 10.1021/jacs.8b02552]

Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells.
Fidelia Ijeoma Uche, James McCullagh, Timothy W.D. Claridge, Alan Richardson, Wen-Wu Li, Bioorg. Med. Chem. Lett., 2018, 28, 1652–1656 [DOI: 10.1016/j.bmcl.2018.03.038]

On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyls.
Younes Fegheh-Hassanpour, Faisal Ebrahim, Tanzeel Arif, Herman O. Sintim, Timothy D. W. Claridge, Nader T. Amin and David M. Hodgson, Org. Biol. Chem., 2018, 16, 2876-2884.  [DOI: 10.1039/C8OB00435H]

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.
Martine I. Abboud, Tom E. McAllister, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Christian Jorgensen, Carmen Domenea, Jasmin Mecinović, Kerstin Lippl, Rebecca L. Hancock, Richard J. Hopkinson, Akane Kawamura, Timothy D. W. Claridge and  Christopher J. Schofield, Chem. Commun., 2018, 54, 3130-3133 [DOI: 10.1039/C8CC00387D]

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.
Martine I. Abboud, Magda Kosmopoulou, Anthony P. Krismanich, Jarrod W. Johnson, Philip Hinchliffe, Jurgen Brem,
Timothy D. W. Claridge, James Spencer, Christopher J. Schofield, and Gary I. Dmitrienko, Chem. Eur. J. 2018, 24, 5734-5737  [DOI: 10.1002/chem.201705886]