NMR Facility

Department of Chemistry University of Oxford

Global Aromaticity and Antiaromaticity in Porphyrin Nanoring Anions.
Martin D. Peeks, Michael Jirasek, Timothy D. W. Claridge and Harry L. Anderson, Angew. Chem. Int. Ed., 2019, [DOI: 10.1002/anie.201909032]

New NOAH Modules for Structure Elucidation at Natural Isotopic Abundance.
Ēriks Kupče  and T. D. W. Claridge, J. Magn. Reson., 2019, [DOI: 10.1016/j.jmr.2019.106568]

19F-NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition.
Emma van Groesen, Christopher T. Lohans, Jürgen Brem, Kristina M. J. Aertker, Timothy D. W. Claridge, and Christopher J. Schofield., Chem. Eur. J., 2019, [DOI: 10.1002/chem.201902529]

Triplet NOAH supersequences optimised for small molecule structure characterisation.
Tim D. W. Claridge, Maksim Mayzel, and Ēriks Kupče, Magn. Reson. Chem., 2019, [DOI:10.1002/mrc.4887]

Electrochemical Oxidation of the Phospha- and Arsa-ethynolate Anions, PCO and AsCO
Frank Tambornino, Eden E. L. Tanner, Hatem M. A. Amin, Jennifer Holter, Tim Claridge, Richard G. Compton, and Jose M. Goicoechea,  Eur. J. Inorg. Chem., 2019, 1644–1649 [DOI: 10.1002/ejic.201801503]

Biocatalytic Production of Bicyclic β-Lactams with Three Contiguous Chiral Centres using Engineered Crotonases.
Refaat Hamed, Ruben Gomez-Castellanos, Luc Henry, Sven Warhaut, Timothy D. W. Claridge, and Christopher Schofield, Nature Comms. Chem., 2019, 2:7 [DOI: 10.1038/s42004-018-0106-z]

Classifying the antibody negative NMO syndromes: clinical, imaging and metabolomic modeling.
Tianrong Yeo, Fay Probert, Maciej Jurynczyk, Megan Sealey, Ana Cavey, Tim D. W. Claridge, Mark R Woodhall, Patrick J. Waters, Maria Isabel S. Leite, Daniel Anthony, and Jacqueline Palace, , Neurol Neuroimmunol Neuroinflamm 2019, 6, e626. [DOI:10.1212/NXI.0000000000000626]
 
Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid.
Maria Chatzopoulou, Tim D. W. Claridge, Kay E. Davies, Stephen G. Davies, David Elsey, Enrico Emer, Ai M. Fletcher, Shawn Harriman, Neil Robinson, Jessica Rowley, Angela J. Russell, Jonathan Tinsley, Richard Weaver, Isabel Wilkinson, Nicky Willis, Francis Wilson, and Graham M. Wynne, J. Med. Chem. 2019, [DOI: 10.1021/acs.jmedchem.9b01547]
 
19F NMR studies on γ-Butyrobetaine Hydroxylase Provide Mechanistic Insights and suggest a dual Inhibition mode.
Robert K. Leśniak, Anna M. Rydzik, Jos J. A. G. Kamps, Amjad Kahn, Timothy D. W. Claridge, and Christopher J. Schofield, Chem. Comm, 2019, 55, 14717-14720  [DOI: 10.1039/C9CC06466D]
 
How formaldehyde reacts with amino acids.
Jos J. A. G. Kamps, Richard J. Hopkinson, Christopher J. Schofield, and Timothy D. W. Claridge, Commun Chem, 2019, 2, 126 [DOI: 10.1038/s42004-019-0224-2]
 
Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis.
Juan A. Aguilar, Julia Cassani, Fay Probert, Jacqueline Palace, Tim D. W. Claridge, Adolfo Botana and Alan M. Kenwright, Analyst, 2019, 144, 7270 - 7277 [DOI: 10.1039/C9AN01005J]