NMR Facility

Department of Chemistry University of Oxford

Impact of Multiple Hydrogen Bonds with Fluoride on Catalysis: Insight from NMR Spectroscopy
Francesco Ibba, Gabriele Pupo, John M. Brown, Timothy D. W. Claridge, and Véronique Gouverneur, J. Am. Chem. Soc., 2020, 142, (46), 19731-19744 [DOI: 10.1021/jacs.0c09832]

Methyl gallate – rich fraction of Syzygium coriaceum Bosser & Guého leaf extract induced cancer cell cytotoxicity via oxidative stress.
Nawraj Rummun, Elisabete Pires, James McCullagh, Timothy W.D. Claridge, Theeshan Bahorun, Wen-Wu Li, Vidushi S. Neergheen-Bhujun, South African Journal of Botany, 2021, 137, 149-158. [DOI: 10.1016/j.sajb.2020.10.014]

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest.
Nawraj Rummun, Philippe Rondeau, Emmanuel Bourdon, Elisabete Pires, James McCullagh, Timothy D. W. Claridge, Theeshan Bahorun, Wen-Wu Li, and Vidushi S. Neergheen. Pharmaceuticals, 2020, 13, 303, [DOI:10.3390/ph13100303]

Post-inflammatory behavioural despair in male mice is associated with reduced cortical glutamate-glutamine ratios, and circulating lipid and energy metabolites.
Shi Yu Chan, Fay Probert, Jennifer C Hebert, Timothy DW Claridge, Daniel C Anthony, Philip WJ Burnet, Scientific Reports, 2020, 10, 16857 [DOI: 10.1038/s41598-020-74008-w]

A blood‑based metabolomics test to distinguish relapsing–remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application.
Tianrong Yeo, Megan Sealey, Yifan Zhou, Luisa Saldana, Samantha Loveless, Timothy D. W. Claridge, Neil Robertson, Gabriele DeLuca, Jacqueline Palace, Daniel C. Anthony & Fay Probert, Sci. Rep., 2020, 10, 12381 [DOI: 10.1038/s41598-020-69119-3]

Reducing agent mediated non-enzymatic conversion of 2-oxoglutarate to succinate – implications for oxygenase assays.
Amjad Khan, Christopher J. Schofield, and Timothy D. W. Claridge, ChemBioChem, 2020, 21, 2898-2902 [DOI: 10.1002/cbic.202000185]

The whole-cell Ca2+ release-activated Ca2+ current ICRAC, is regulated by the mitochondrial CA2+ uniporter channel and is independent of extracellular and cytosolic Na. 
Krishna Samanta, Daniel Bakoswki, Nader Amin, and Anant B. Parekh, J. Physiol., 2020, 598, 1753-1773 [DOI: 10.1113/JP276551]

NMR waterLOGSY as An Assay in Drug Development Programmes for Detecting Protein-Ligand Interactions–NMR waterLOGSY.
Carole J. R. Bataille, Terence H. Rabbitts, and Timothy D. Claridge, Bio-protocol 10(13): e3666. [DOI: 10.21769/BioProtoc.3666] 

Monitoring protein-metal binding by 19F NMR – Case study with the New Delhi metallo-β-lactamase 1.
Anna M. Rydzik, Jürgen Brem, Timothy D. W. Claridge, and Christopher J. Schofield, RSC Med. Chem., 2020,11, 387-391 [DOI: 10.1039/c9md00416e] 

Global Aromaticity at the Nanoscale
Michel Rickhaus, Michael Jirasek, Lara Tejerina, Henrik Gotfredsen, Martin D. Peeks, Renée Haver, Hua-Wei Jiang, Timothy D. W. Claridge, and Harry L. Anderson, Nat. Chem., 2020, 12, 236–241 [DOI: 10.1038/s41557-019-0398-3]

Studies on the Selectivity of Proline Hydroxylases Reveal New Substrates Including Bicycles
Tristan J. Smart, Refaat B. Hamed, Timothy D. W. Claridge, Christopher J. Schofield, Bioorganic Chemistry, 2020, 94 103386 [DOI: 10.1016/j.bioorg.2019.103386]