NMR Facility

Department of Chemistry University of Oxford

Time-efficient NMR "supersequences" termed NOAH (NMR by Ordered Acquisition using 1H detection) can provide a significant reduction in the time required for collecting 2D data sets used for the characterisation of small molecules. These experiments work by nesting multiple conventional 2D experiments into one, thereby reducing the number of lengthy magnetisation recovery delays required in data acquisition. This work is in collaboration with Ēriks Kupče of Bruker Biospin UK.

The latest pulse programs and associated AU scripts will soon be provided here, along with instructions for implementing NOAH experiments on Bruker spectrometers. Latest releases can also be found in the Bruker pulse program on-line user library.

Publications

Triplet NOAH supersequences optimised for small molecule structure characterisation.
Tim D. W. Claridge, Maksim Mayzel, and Ēriks Kupče.
Magn. Reson. Chem., 2019 [DOI:10.1002/mrc.4887]

Molecular Structure from a Single NMR Supersequence.
Ēriks Kupče and Tim D. W. Claridge.
Chem. Comm., 2018, 54, 7139-7142 [DOI: 10.1039/C8CC03296C]

NOAH – NMR Supersequences for Small Molecule Analysis and Structure Elucidation.
Ēriks Kupče and Tim D. W. Claridge.
Angew. Chem. Int. Ed., 2017, 56, 11779-11783 [DOI: 10.1002/anie.201705506]

Pulse programs

Single letter codes are used to indicate the modules nested within each NOAH experiment:

C=COSY, S=HSQC, M=HMQC, B=HMBC, D=DQF-COSY, T=TOCSY, N=NOESY, R=ROESY

Further modifiers indicate refinements within each combination:

qf=magnitude mode module (usually COSY), clip=CLIP-COSY variant, ad=Adiabatic off-resonance ROESY

noah2_BS
noah2_SC
noah2_SCqf
noah2_SCclip
noah2_CN

noah3_BSC
noah3_BSCqf
noah3_BSCclip
noah3_BSD
noah3_BST
noah3_BSN
noah3_BSR
noah3_BSRad

noah4_BSCN
noah4_BSCT
noah4_MSCN

noah5_MSBCN