NMR Facility

Department of Chemistry University of Oxford

This page summarises books, book sections and journal publications to which I have contributed. 

Books

Introduction to Organic Spectroscopy

L. M. Harwood and T. D. W. Claridge, OUP, Oxford, 1997.

1999: Available in Japanese
This book is an undergraduate text book produced for Oxford Unversity Press as part of the Oxford Chemistry Primer series.

 


High-Resolution NMR Techniques in Organic Chemistry (3rd Edition)

T. D. W. Claridge, Elsevier, Oxford, 2016

The latest updated and extended edition of the widely acclaimed text.

 

 

High-Resolution NMR Techniques in Organic Chemistry (2nd Edition)

T. D. W. Claridge, Elsevier, Oxford, 2009

A fully updated and extended edition of the widely acclaimed first edition.

This was produced for Elsevier Science, as part of the Tetrahedron series.

 

High-Resolution NMR Techniques in Organic Chemistry

T. D. W. Claridge, Pergamon, Oxford, 1999.

This is a graduate/advanced undergraduate level text that is also well suited to chemists and spectroscopists in industry.

It was produced for Pergamon Press originally as part of the Tetrahedron series of books.
2003: Reprinted [with corrections]; 2004: Available in Japanese


Multidimensional NMR Methods for the Solution State

G. A. Morris and J. W. Emsley (Eds), Wiley, 2010

This is collection of articles describing solution state NMR methods.

I contributed Chapter 16 on TOCSY.

 


Papers

2017

184) Mechanistic studies on a Cu-catalysed asymmetric allylic alkylation with cyclic racemic starting materials.
Emeline Rideau, Hengzhi You, Mireia Sidera, Timothy D. W. Claridge, Stephen P. Fletcher, J. Am. Chem. Soc. 2017, 139, 5614−5624. [DOI: 10.1021/jacs.7b02440]

183) Monitoring the Disassembly of Virus-like Particles by 19F NMR.
Rogen L. C. Leung, Matthew D. M. Robinson, Alaa A. A. Ajabali, Gogulan Karunanithy, Brian Lyons, Ritu Raj, Saeed Raoufmoghaddam, Shabaz Mohammed, Timothy D. W. Claridge, Andrew J. Baldwin and Benjamin G. Davis, J. Am. Chem. Soc. 2017, 139, 5277−5280. [DOI: 10.1021/jacs.6b11040]

182) 19F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paolo Metallo-β-Lactamase.
Martine I. Abboud, Jürgen Brem, Philip Hinchliffe, Robert Macsics, Inga Pfeffer, Anne Makena, Klaus-Daniel Umland, Anna M. Rydzik, Guo-Bo Li, James Spencer, Timothy D.W. Claridge, and Christopher J. Schofield, Angew. Chem. Int. Ed. 2017, 56, 3862 –3866. [DOI: 10.1002/anie.201612185]

181) Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.
Renjie Huang, Arnaud Bonnichon, Timothy D. W. Claridge, Ivanhoe K. H. Leung, Sci. Reps. 2017, 7, 43727; [DOI: 10.1038/srep43727]

180) A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.
Omar Aldulaimi, Fidelia I. Uche, Hamza Hameed, Haddijatou Mbye, Imran Ullah, Falko Drijfhout, Timothy D.W. Claridge, Paul Horrocks, Wen-Wu Li, Journal of Ethnopharmacology, 2017, 198, 221–225. [DOI: 10.1016/j.jep.2017.01.014]

179) Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes.
Refaat B. Hamed, Luc Henry, Timothy D. W. Claridge, and Christopher J. Schofield, ACS Catalysis, 2017, 7, 1279−1285. [DOI: 10.1021/acscatal.6b02509]

178) Aromatic and antiaromatic ring currents in a molecular nanoring.
Martin D. Peeks, Timothy D. W. Claridge, Harry L. Anderson, Nature, 2017, 541, 200-203. [DOI: 10.1038/nature20798]

2016

177) Post-translational mutagenesis: A chemical synthetic strategy for exploration of protein side-chain diversity.
Tom H. Wright, Ben J. Bower, Justin M. Chalker, Gonçalo J. L. Bernardes, Rafal Wiewiora, Wai-Lung Ng, Ritu Raj, Sarah Faulkner, M. Robert J. Vallée, Anuchit Phanumartwiwath, Oliver D. Coleman, Marie-Laëtitia Thézénas, Maola Khan, Sébastien R. G. Galan, Lukas Lercher, Matthew W. Schombs, Stefanie Gerstberger, Maria E. Palm-Espling, Andrew J. Baldwin, Benedikt M. Kessler, Timothy D. W. Claridge, Shabaz Mohammed, Benjamin G. Davis, Science, 2016, Vol. 354, Issue 6312 [DOI: 10.1126/science.aag1465].

176) Early diagnosis of brain metastases using a biofluids-metabolomics approach in mice.
James R. Larkin, Alex M. Dickens, Timothy D. W. Claridge, Claire Bristow, Kleopatra Andreou, Daniel C. Anthony, Nicola R. Sibson, Theranostics, 2016, 6, 2161-2169 [DOI: 10.7150/thno.16538]

175) Torsional and Electronic Factors Control the C−H⋅⋅⋅O Interaction.
R. W. Driver, T. D. W. Claridge, S. Scheiner, M. D. Smith, Chem. Eur. J. 2016, 22, 16513-16521. [DOI: 10.1002/chem.201602905]

174) Normal tissue radioprotection by amifostine via Warburg-type effects.
Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis & Adrian L. Harris, Sci. Rep., 2016, 6, 30986. [DOI: 10.1038/srep30986]

173) Interaction of Avibactam with Class B Metallo-β-lactamases.
Martine I. Abboud, Christian Damblon, Jürgen Brem, Nicolas Smargiasso, Paola Mercuri, Bernard Gilbert, Anna M. Rydzik,Timothy D. W. Claridge, Christopher J. Schofield, and Jean-Marie Frère, Antimicrob. Agents Chemother., 2016, 60, 5655–5662 [DOI:10.1128/AAC.00897-16]

172) Nanorings with Copper(II) and Zinc(II) Centers: Forcing Copper Porphyrins to Bind Axial Ligands in Heterometallated Oligomers.
Jonathan Cremers, Sabine Richert, Dmitry V. Kondratuk, Tim D. W. Claridge, Christiane R. Timmel, and Harry L. Anderson, Chemical Science, 2016, [DOI: 10.1039/C6SC01809B]

171) Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya-Min Tian, Martine I. Abboud, Wei Ge, Carmen Domene, François-Xavier Cantrelle, Isabelle Landrieu, Adam P. Hardy, Christopher W. Pugh, Peter J. Ratcliffe, Timothy D. W. Claridge & Christopher J. Schofield, Nat. Commun. 2016, 7:12673, [doi: 10.1038/ncomms12673].

170) Scalar cross-relaxation detected in the NOESY spectra of Oxazolidines and Thiazolidines.
Tharindi D. Panduwawala, Laia Josa-Culleré, Ilya Kuprov, Barbara Odell, Mark G. Moloney, and Timothy D. W. Claridge, J. Org. Chem. 2016, 81, 4142-4148 [DOI: 10.1021/acs.joc.6b00458]

169) Structure and dynamics of supramolecular assemblies from NMR relaxation interference measurements.
Gogulan Karunanithy, Arjen Cnossen, Henrik Müller, Martin D. Peeks, Nicholas H. Rees, Timothy D. W. Claridge, Harry L. Anderson and Andrew J. Baldwin, Chem. Comm. 2016, 52, 7450-7453 [DOI: 10.1039/C6CC02544G]

168) Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.
Sook Y. Lee, Jürgen Brem, Ilaria Pettinati, Timothy D. W. Claridge, Opher Gileadi, Christopher J. Schofield and Peter J. McHugh, Chem. Comm., 2016, 52, 6727-6730. [DOI: 10.1039/C6CC00529B]

167) Development and applications of an efficient NMR ligand-based binding assay for γ-butyrobetaine hydroxylase (BBOX).
Amjad Khan, Robert K. Lesniak, Anna M. Rydzik, Hwanho Choi, Ivanhoe K. H. Leung, Jürgen Brem, Michael A. McDonough, Christopher J. Schofield, and Timothy D. W. Claridge, MedChemComm, 2016, 7, 873-880. [DOI: 10.1039/C6MD00004E]

166) Synthesis and Characterization of a Novel N-F Reagent derived from the Ethano-Tröger’s Base:  1JFN Coupling Constant as Signature for the N-F Bond.
Raul Pereira, Jamie Wolstenhulme, Graham Sandford, Timothy D. W. Claridge, Véronique Gouverneur and Jan Cvengroš, Chem. Comm, 2016, 52, 1606-1609. [DOI: 10.1039/C5CC08375C]

2015

165) Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans.
Richard J. Hopkinson , Ivanhoe K. H. Leung, Tristan J. Smart, Nathan R. Rose, Luc Henry, Timothy D. W. Claridge, Christopher J. Schofield, PLoS ONE, 10(12):e0145085 [DOI: 10.1371/journal.pone.0145085]

164) Cation-π interactions contribute to substrate recognition in γ-butyrobetaine hydroxylase catalysis.
Jos J. A. G. Kamps, Amjad Khan, Hwanho Choi, Robert K. Lesniak, Jürgen Brem, Anna M. Rydzik, Michael A. McDonough, Christopher J. Schofield, Timothy D. W. Claridge and Jasmin Mecinović,  Chem. Eur. J., 2015, 22, 1270-1276 [DOI: 10.1002/chem.201503761]

163) Self-Assembly of Russian Doll Concentric Porphyrin Nanorings.
Sophie A. L. Rousseaux, Juliane Q. Gong, Rene!e Haver, Barbara Odell, Tim D. W. Claridge, Laura M. Herz, and Harry L. Anderson, J. Am. Chem. Soc., 2015, 137, 12713-12718. [DOI: 10.1021/jacs.5b07956].

162) Barrierless Photoisomerization of 11-cis Retinal Protonated Schiff Base in Solution.
Giovanni Bassolino, Tina Sovdat, Alex Soares Duarte, Jong Min Lim, Christoph Schnedermann, Matz Liebel, Barbara Odell, Timothy D.W. Claridge, Stephen P. Fletcher, Philipp Kukura, J. Am. Chem. Soc., 2015, 137, 12434–12437. [DOI: 10.1021/jacs.5b06492].

161) α- and α′-Lithiation−Electrophile Trapping of N-Thiopivaloyl and N-tert-Butoxythiocarbonyl α-Substituted Azetidines: Rationalization of the Regiodivergence Using NMR and Computation.
Kelvin E. Jackson, Claire L. Mortimer, Barbara Odell, Jeffrey M. McKenna, Timothy D. W. Claridge, Robert S. Paton, and David M. Hodgson, J. Org. Chem., 2015, 80, 9838-9846. [DOI: 10.1021/acs.joc.5b01804]

160) Urinary Excretion and Metabolism of Miglustat and Valproate in Patients with Niemann-Pick Type C1 Disease: One- and Two-Dimensional Solution-State 1H NMR Studies.
Fay Probert, Victor Ruiz-Rodado, Xiaoyu Zhang, Danielle te Vruchte,Tim D.W. Claridge, Mark Edgar, Anna Zonato Tocchio, Robin H. Lachmann,Frances M. Platt, Martin Grootveld, J. Pharm. Biomed. Anal., 2016, 117, 276–288. [DOI: 10.1016/j.jpba.2015.08.011]

159) The Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor N-oxalylglycine is present in Rhubarb and Spinach Leaves.
Khalid Al-Qahtani, Bushra Jabeen, Rok Sekirnik, Naheed Riaz, Timothy D.W. Claridge, Christopher J. Schofield, James S.O. McCullagh, Phytochemistry, 2015, 117, 456-461. [DOI: 10.1016/j.phytochem.2015.06.028]

158) NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis.
Alex M. Dickens, James R. Larkin, Benjamin G. Davis, Julian L. Griffin, Timothy D. W. Claridge, Nicola R. Sibson, Daniel C. Anthony. J. Neuroimmune Pharmacol., 2015, 10, 435-444. [DOI: 10.1007/s11481-015-9622-0]

157) Glycosyldiselenides as lectin ligands detectable by NMR in biofluids.
Ignacio Pérez-Victoria, Omar Boutureira, Tim D. W. Claridge and Benjamin G. Davis, Chem. Comm, 2015, 51, 12208-12211. [DOI: 10.1039/c5cc03952e]

156) The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis.
Elizabeth Gray, James R. Larkin, Tim D. W. Claridge, Kevin Talbot, Nicola R. Sibson, and Martin R. Turner, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2015, 1-8 [DOI:10.3109/21678421.2015.105349]

155) Potent and Selective Triazole-based Inhibitors of the Hypoxia-inducible Factor Prolyl-hydroxylases with Activity in the Murine Brain.
Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M. Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D. W. Claridge, Akane Kawamura, Christopher W. Pugh, Peter J. Ratcliffe, Christopher J. Schofield, PLoS ONE 10(7): e0132004. [DOI:10.1371/journal.pone.0132004]

154) Fluorophosphate Nucleotide Analogs as Versatile Tools for 19F NMR Studies.
Marek R. Baranowski, Anna Nowicka, Anna M. Rydzik, Marcin Warminski, Renata Kasprzyk, Blazej A. Wojtczak, Jacek Wojcik, Timothy D. W. Claridge, Joanna Kowalska, Jacek Jemielity, J. Org. Chem., 2015, 80, 3982-3997. [DOI: 10.1021/acs.joc.5b00337]

153) Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients.
A. M. Dickens, D. C. Anthony, R. Deutsch, M. M. Mielke, T. D. W. Claridge, I. Grant, D. Franklin, D. Rosario, T. Marcotte,  S. Letendre, J. C.  McArthur, N. J.Haughey,  AIDS, 2015, 29, 559-569 [DOI: 10.1097/QAD.0000000000000580].

152) Caterpillar Track Complexes in Template-Directed Synthesis and Correlated Molecular Motion.
Shiqi Liu, Dmitry V. Kondratuk, Sophie A. L. Rousseaux, Guzmµn Gil-Ramírez, Melanie C. O’Sullivan, Jonathan Cremers, Tim D. W. Claridge, and Harry L. Anderson. Angew. Chem. Int. Ed. 2015, 54, 5355–5359 [DOI: 10.1002/anie.201412293]

151) Anomalous Nuclear Overhauser Effects in Carbon-Substituted Aziridines: Scalar Cross-Relaxation of the First Kind.
Ilya Kuprov, David M. Hodgson, Johannes Kloesges, Christopher I. Pearson, Barbara Odell, and Timothy D. W. Claridge, Angew. Chem. Int. Ed. 2015, 54, 3697-3701. [DOI: 10.1002/anie.201410271]

150) Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1.
Jürgen Brem, Weston B. Struwe, Anna M. Rydzik, Hanna Tarhonskaya, Inga Pfeffer, Emily Flashman, Sander S. van Berkel, James Spencer, Timothy D. W. Claridge, Michael A. McDonough, Justin L. P. Benesch and Christopher J. Schofield, Chemical Science, 2015, 6, 956-963. [DOI 10.1039/C4SC01752H]

2014

149) Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
Hanna Tarhonskaya, Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Nikita D. Loik, James S. O. McCullagh, Timothy D. W. Claridge, Christopher J. Schofield and Emily Flashman, Biochem. J., 2014, 463, 363–372. [doi:10.1042/BJ20140779]

148) Rhodanine Hydrolysis Leads to Potent Thioenolate Mediated Metallo-β-Lactamase inhibition.
Jürgen Brem, Sander S. van Berkel, WeiShen Aik, Anna Rydzik, Matthew B. Avison, Ilaria Pettinati, Klaus-Daniel Umland, Akane Kawamura, James Spencer, Timothy D.W. Claridge, Michael A. McDonough, and Christopher J. Schofield. Nature Chem. 2014, 6, 1084-1090. [DOI:10.1038/nchem.2110]

147) A type-II biomarker for differentiating relapsing remitting from secondary progressive multiple sclerosis.
 A.M. Dickens, J.R. Larkin, J. L. Griffin, A. Cavey, L. Matthews, M.R. Turner, G.K. Wilcock, B.G. Davis, T.D.W. Claridge, J. Palace, D.C. Anthony, N.R. Sibson, Neurology, 2014, 83, 1492-1499. [doi: 10.1212/WNL.0000000000000905].

146) Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
John S. Scotti, Ivanhoe K. H. Leung, Wei Ge, Michael A. Bentley, Jordi Paps, Holger B. Kramer, Joongoo Lee, WeiShen Aik, Hwanho Choi, Steinar M. Paulsen, Lesley A. H. Bowman, Nikita D. Loik, Shoichiro Horita, Chia-hua Ho, Nadia J. Kershaw, Christoph M. Tang, Timothy D. W. Claridge, Gail M. Preston, Michael A. McDonough, and Christopher J. Schofield, Proc. Natl. Acad. Sci., 2014, 111, 13331-13336. [DOI:10.1073/pnas.1409916111].

145) Oxygenase-Catalysed Desymmetrisation of N,N-Dialkyl Piperidine-4-carboxylic acids.
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Michael A. McDonough, Timothy D. W. Claridge and Christopher J. Schofield, Angew. Chem. Int. Ed. 2014, 53, 10925 –10927 [DOI: 10.1002/anie.201406125]

144) Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Nikita D. Loik,  Luc Henry,  Michael A. McDonough,  Timothy D. W. Claridge and Christopher J. Schofield, Org. Biomol. Chem, 2014, 12, 6354–6358. [DOI: 10.1039/C4OB01167H]

143) Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases.
Hanna Tarhonskaya, Andrea Szöllössi, Ivanhoe K. H. Leung, Jacob T. Bush, Luc Henry, Rasheduzzaman Chowdhury, Aman Iqbal, Timothy D. W. Claridge, Christopher J. Schofield, and Emily Flashman, Biochemistry, 2014, 53, 2483−2493. [DOI: 10.1021/bi500086p].

142) Non-Enzymatic Chemistry Enables 2-Hydroxyglutarate Mediated Activation of 2-Oxoglutarate Oxygenases.
Hanna Tarhonskaya, Anna M. Rydzik, Ivanhoe K. H. Leung, Nikita D. Loik, Mun Chiang Chan, Akane Kawamura, James S. O. McCullagh, Timothy D. W. Claridge, Emily Flashman and Christopher J. Schofield, Nat. Commun., 2014, 5, 3423 [DOI:10.1038/ncomms4423]

141) Monitoring conformational changes in the NDM-1 Metallo-β-lactamase by 19F NMR.
Anna M. Rydzik, Jürgen Brem, Sander S. van Berkel, Inga Pfeffer, Anne Makena, Timothy D. W. Claridge, Christopher J. Schofield, Angew. Chem. Int. Ed. Engl., 2014, 53, 3129-3133. [DOI: 10.1002/anie.201310866]

140) Synthetic control of retinal photochemistry and photophysics in solution.
Giovanni Bassolino, Tina Sovdat, Matz Liebel, Christoph Schnedermann, Barbara Odell, Timothy D.W. Claridge, Philipp Kukura, Stephen P. Fletcher J. Am. Chem. Soc., 2014, 136, 2650-2658. [DOI: 10.1021/ja4121814]

139) Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications.
Anna M. Rydzik, Ivanhoe K. H. Leung, Armin Thalhammer,  Grazyna T. Kochan, Timothy D. W. Claridge  and Christopher J. Schofield, Chem. Commun., 2014, 50, 1175-1177 [DOI: 10.1039/c3cc47581f]

2013

138) Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.
Refaat B. Hamed, Luc Henry, J. Ruben Gomez-Castellanos, Amina Asghar, Jürgen Brem, Timothy D. W. Claridge  and Christopher J. Schofield, Org. Biomol. Chem., 2013, 11, 8191-8196, [DOI: 10.1039/c3ob41525b]

137) Solution phase structures of enantiopure and racemic lithium N-benzyl-N-(α-methylbenzyl)amide in THF: low temperature 6Li and 15N NMR spectroscopic studies.
Timothy D. W. Claridge, Stephen G. Davies, Dennis Kruchinin, Barbara Odell, Paul M. Roberts, Angela J. Russell, James E. Thomson, Steven M. Toms. Tetrahedron: Asymmetry, 2013, 24, 947–952. [DOI: 10.1016/j.tetasy.2013.07.001]

136) A Discrete Three-Layer Stack Aggregate of a Linear Porphyrin Tetramer: Solution-Phase Structure Elucidation by NMR and X-Ray Scattering.
Marie Hutin, Johannes K. Sprafke, Barbara Odell, Harry L. Anderson and Tim D. W. Claridge, J. Am. Chem. Soc., 2013, 135, 12798−12807 [DOI: 10.1021/ja406015r]

135) Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Sander S. van Berkel, Joanne E. Nettleship, Ivanhoe K. H. Leung, Jürgen Brem, Hwanho Choi, David I. Stuart, Timothy D. W. Claridge, Michael A. McDonough, Raymond J. Owens, Jingshan Ren, Christopher J. Schofield, ACS Chem. Biol., 2013, 8, 2112-2116 [DOI: 10.1021/cb400200h]

134) Chiral Recognition in Contact Ion-pairs; Observation, Characterization and Analysis.
J. A. Raskatov, A. L. Thompson, A. R. Cowley, T. D. W. Claridge and J. M. Brown, Chem. Sci., 2013, 4, 3140 – 3147 [DOI: 10.1039/c3sc51096d]

133)  Is JmjC Oxygenase Catalysis Limited to Demethylation?
Richard J. Hopkinson, Louise J. Walport, Martin Münzel, Nathan R. Rose, Tristan J. Smart, Akane Kawamura, Timothy D. W. Claridge and Christopher J. Schofield, Angew. Chem. Int. Ed. Engl., 2013, 52, 7709-7713. [DOI: 10.1002/anie.201303282]

132) Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor
Ming Yang, Adam P. Hardy, Rasheduzzaman Chowdhury, Nikita D. Loik, John S. Scotti, James S. O. McCullagh, Timothy D. W. Claridge, Michael A. McDonough, Wei Ge and Christopher J. Schofield, Angew. Chem. Int. Ed. Engl., 2013,  52,1700-1704. [DOI: 10.1002/anie.201208046]

131) Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors
Ivanhoe K. H. Leung, Marina Demetriades, Adam P. Hardy, Clarisse Lejeune, Tristan J. Smart, Andrea Szöllössi, Akane Kawamura, Christopher J. Schofield, Timothy D. W. Claridge, J. Med. Chem., 2013, 56, 547-555. [DOI: 10.1021/jm301583m]

130) Acceleration of the Eschenmoser coupling reaction by sonication: efficient synthesis of enaminones
Naga Durgarao Koduri, Bethany Hileman, Justin D. Cox, Halee Scott, Phuong Hoang, Alexa Robbins, Kyle Bowers, Lemma Tsebaot, Kun Miao, Maria Castaneda, Michael Coffin, Guan Wei, Tim D. W. Claridge, Kenneth P. Roberts and Syed Raziullah Hussaini, RSC Adv., 2013, 3, 181-188. [DOI: 10.1039/c2ra22033d]

2012

 129)  Oxygenase Catalysed Ribosome Hydroxylation Occurs in Prokaryotes and Humans
Wei Ge, Alexander Wolf, Tianshu Feng, Chia-hua Ho, Rok Sekirnik, Adam Zayer, Nicolas Granatino, Matthew E. Cockman, Christoph Loenarz, Nikita D. Loik, Adam P. Hardy, Timothy D.W. Claridge, Refaat B. Hamed, Rasheduzzaman Chowdhury, Lingzhi Gong, Carol V. Robinson, David C. Trudgian, Miao Jiang, Mukram M. Mackeen, James S. Mccullagh, Yuliya Gordiyenko, Armin Thalhammer, Atsushi Yamamoto, Ming Yang, Phebee Liu-Yi, Zhihong Zhang, Marion Schmidt-Zachmann, Benedikt M. Kessler, Peter J. Ratcliffe, Gail M. Preston, Mathew L. Coleman, Christopher J. Schofield, Nature Chem. Biol., 2012, 8, 960-962. [DOI: 10.1038/NChemBio.1093]

128) Conformational analysis of fluorinated pyrrolidines using 19F-1H scalar couplings and heteronuclear nOes
Lorraine E. Combettes, Philip Clausen-Thue, Mike King, Barbara Odell, Amber L. Thompson, Véronique Gouverneur, and Tim D. W. Claridge, Chem. Eur. J, 2012, 18, 13133-13141. [DOI: 10.1002/chem.201201577]

127)  Synthesis of 3-Fluoropyrrolidines and 4-Fluoropyrrolidin-2-ones from Allylic Fluorides
Lorraine E. Combettes, Marie Schuler, Rakesh Patel, Baltasar Bonillo, Barbara Odell, Amber L. Thompson, Tim D. W. Claridge, and Véronique Gouverneur, Chem. Eur. J, 2012, 18, 13126-13132. [DOI: 10.1002/chem.201201576]

126) Ammonium-Directed Olefinic Epoxidation: Kinetic and Mechanistic Insights
Méabh B. Brennan, Timothy D. W. Claridge, Richard G. Compton, Stephen G. Davies, Ai M. Fletcher, Martin C. Henstridge, David S. Hewings, Wataru Kurosawa, James A. Lee, Paul M. Roberts, Anne K. Schoonen, and James E. Thomson, J. Org. Chem, 2012, 77, 7241-7261. [DOI: 10.1021/jo3010556]

125) γ-Butyrobetaine Hydroxylase Catalyses a Stevens Type Rearrangement.
Luc Henry, Ivanhoe K. H. Leung, Timothy D. W. Claridge, Christopher J. Schofield, Biorg. Med. Chem. Lett., 2012, 22, 4975-4978. [DOI: 10.1016/j.bmcl.2012.06.024]

124) Development and application of a fluoride detection based fluorescence assay for γ-butyrobetaine hydroxylase
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Armin Thalhammer, Udo Oppermann, Timothy D. W. Claridge and Christopher J. Schofield, ChemBioChem, 2012, 13, 1559–1563. [DOI: 10.1002/cbic.201200256]

123) Fluorescent Charge-Assisted Halogen-Bonding Macrocyclic Halo-Imidazolium Receptors for Anion Recognition and Sensing in Aqueous Media
Fabiola Zapata, Antonio Caballero, Nicholas G. White, Tim D. W. Claridge, Paulo J. Costa, Vitor Felix and Paul D. Beer, J. Am. Chem. Soc., 2012, 134, 11533-11541. [DOI: 10.1021/ja302213r]

122) Conformational Effects in Sugar Ions: Spectroscopic Investigations in the Gas Phase and in Solution
Ram Sagar, Svemir Rudić,  David P. Gamblin, Eoin M. Scanlan, Timothy D. Vaden, Barbara Odell, Timothy D.W. Claridge, John P. Simons and Benjamin G. Davis, Chem. Sci., 2012, 3, 2307-2313 [DOI:10.1039/C2SC20341C]

121) Dynamic Chemistry Employing Boronic Acids / Boronate Esters Leads to Potent Oxygenase Inhibitors
Marina Demetriades, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Mun Chiang Chan,  Kar Kheng Yeoh,Ya-Min Tian, Timothy D.W Claridge, Peter J. Ratcliffe, Esther C. Y. Woon,  Christopher J. Schofield, Angew. Chem. Int. Ed. Engl., 2012, 51, 6672-6675.  [DOI: 10.1002/anie.201202000]

120) Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
Refaat B. Hamed, Luc Henry, J. Ruben Gomez-Castellanos, Jasmin Mecinović, Christian Ducho, John L. Sorensen, Timothy D. W. Claridge, and Christopher J. Schofield, J. Am. Chem. Soc., 2012, 134, 471-479. [DOI: 10.1021/ja208318d]

2011 

119) Factor-Inhibiting Hypoxia-Inducible Factor (FIH) Catalyses the Post-translational Hydroxylation of Histidinyl Residues within Ankyrin Repeat Domains
Ming Yang, Rasheduzzaman Chowdhury, Wei Ge, Refaat B. Hamed, Michael A. McDonough, Timothy D. W. Claridge, Benedikt M. Kessler, Matthew E. Cockman, Peter J. Ratcliffe and Christopher J. Schofield, FEBS Lett., 2011, 278, 1086-1097. [DOI:10.1111/j.1742-4658.2011.08022.x]

118) Dimeric Self-Association of an Isophthalamide Macrocycle in Solution and the Solid State
Christopher J. Serpell, Owen Thomas, Barbara Odell, Timothy D. W. Claridge, Ricky Chall, Amber L. Thompson, and Paul D. Beer, Cryst. Eng. Comm., 2011, 13, 4586-4591 [DOI: 10.1039/C1CE05271C]

117) All-or-Nothing Cooperative Self-Assembly of an Annulene Sandwich
Johannes K. Sprafke, Barbara Odell, Timothy D. W. Claridge and Harry L. Anderson, Angew. Chem. Int. Ed. Engl., 2011, 50, 5572-5575. [DOI: 10.1002/anie.201008087]

116) An approach to enzyme inhibition employing reversible boronate ester formation
Ivanhoe K. H. Leung, Tom Brown Jr, Christopher J. Schofield, Timothy D. W. Claridge., Med. Chem. Comm., 2011,  2, 390-395. [DOI: 10.1039/c1md00011j]

115) Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases
Refaat B. Hamed, J. Ruben Gomez-Castellanos, Armin Thalhammer, Daniel Harding, Christian Ducho, Timothy D. W. Claridge, and Christopher J. Schofield., Nature Chem., 2011, 3, 365-371. [DOI: 10.1038/NCHEM.1011]

 114) The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Rasheduzzaman Chowdhury, Kar Kheng Yeoh, Ya-Min Tian, Lars Hillringhaus, Eleanor A. Bagg, Nathan R. Rose, Ivanhoe K.H. Leung, Xuan S. Li, Esther C.Y. Woon, Ming Yang, Michael A.McDonough, Oliver N. King, Ian J. Clifton, Robert J. Klose, Timothy D.W. Claridge, Peter J. Ratcliffe, Christopher J. Schofield & Akane Kawamura, EMBO Reports, 2011,  12, 463-469. [DOI:10.1038/embor.2011.43]

113) A systematic study of the solid state and solution phase conformational preferences of b-peptides derived from C(3)-alkyl substituted transpentacin derivatives
Elin Abraham, Timothy D.W. Claridge, Stephen G. Davies , Barbara Odell, Paul M. Roberts, Angela J. Russell, Andrew D. Smith, Lorna J. Smith, Helen R. Storr, Miles J. Sweet, Amber L. Thompson, James E. Thomson, George E. Tranter, David J. Watkin, Tet. Asymm., 2011, 22, 69-100. [DOI:10.1016/j.tetasy.2010.12.007]

112) Asparagine and aspartate hydroxylation of the cytoskeletal Ankyrin family is catalysed by Factor-Inhibiting Hypoxia-Inducible Factor
Ming Yang, Wei Ge, Rasheduzzaman Chowdhury, Timothy D. W. Claridge, Holger B. Kramer, Bernhard Schmierer, Michael A. McDonough, Lingzhi Gong, Benedikt M. Kessler, Peter J. Ratcliffe, Mathew L. Coleman, and Christopher J. Schofield, J. Biol. Chem., 2011, 286, 7648-7660. [DOI:10.1074/jbc.M110.193540]

111) The 2-Oxoglutarate Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues
Monica Mantri, Nikita D. Loik, Refaat B. Hamed, Timothy D. W. Claridge, James S. O. McCullagh, Christopher J. Schofield, ChemBioChem, 2011, 12, 531-534. [DOI: 10.1002/cbic.201000641]

110) Tuning the cavity of cyclodextrins: altered sugar adaptors in protein pores
Wen-Wu Li, Timothy D.W. Claridge, Qiuhong Li, Mark R. Wormald, Benjamin G. Davis and Hagan Bayley,  J. Am. Chem. Soc., 2011, 133, 1987-2001. [DOI: 10.1021/ja1100867]

109) Vernier Templating and Synthesis of a 12-Porphyrin Nano-ring
Melanie C. O’Sullivan, Johannes K. Sprafke, Dmitry V. Kondratuk, Corentin Rinfray, Timothy D. W. Claridge, Alex Saywell, Matthew O. Blunt, James N. O’Shea, Peter H. Beton, Marc Malfois & Harry L. Anderson, Nature, 2011, 469, 72-75. [DOI:10.1038/nature09683]

2010 

108) Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase
Ivanhoe K.H. Leung, Tobias J. Krojer, Grazyna T. Kochan , Luc Henry, Frank von Delft, Timothy D. W. Claridge, Udo Oppermann, Michael A. McDonough, and Christopher J. Schofield, Chemistry & Biology, 2010, 17, 1316-1324. [DOI:10.1016/j.chembiol.2010.09.016]

107) Studies on the reaction of glutathione and formaldehyde using NMR
Richard J. Hopkinson, Philippa S. Barlow, Christopher J. Schofield and Timothy D. W. Claridge, Org. Biomol. Chem., 2010, 8, 4915-4920.  [DOI: 10.1039/C0OB00208A]

106) A systematic study of the solid state and solution phase conformational preferences of β-peptides derived from transpentacin
Elin Abraham, Callum W. Bailey, Timothy D. W. Claridge, Stephen G. Davies, Kenneth B. Ling, Barbara Odell, Thomas L. Rees, Paul M. Roberts, Angela J. Russell, Andrew D. Smith, Lorna J. Smith, Helen R. Storr, Miles J. Sweet, Amber L. Thompson, James E. Thomson, George E. Tranter, David J. Watkin, Tet. Asymm., 2010, 21, 1797-1815. [DOI:10.1016/j.tetasy.2010.06.001]

105) Structure and reactivity of bicyclic methylene aziridines prepared by intramolecular aziridination of allenes
Jeremy Robertson, George C. Feast, Louise V. White, Victoria A. Steadman (n´ee Doughty) and Timothy D. W. Claridge, Org. Biomol. Chem., 2010, 8, 3060-3063 [DOI: 10.1039/c003693e]

104) Monitoring the Activity of 2-Oxoglutarate Dependent Histone Demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde
Richard J. Hopkinson, Refaat B. Hamed, Nathan R. Rose, Timothy D. W. Claridge, and Christopher J. Schofield, ChemBioChem, 2010, 11, 506-510. [DOI: 10.1002/ cbic.200900713.]

103) Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
Refaat B. Hamed, Jasmin Mecinovic , Christian Ducho, Timothy D. W. Claridge and Christopher J. Schofield, Chem. Commun., 2010, 46, 1413 – 1415. [DOI: 10.1039/b924519g]

102) Group epitope mapping considering relaxation of the ligand (GEM-CRL): Including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments
Sebastian Kemper, Mitul K. Patel, James C. Errey, Benjamin G. Davis, Jonathan A. Jones, Timothy D. W. Claridge, J. Magn. Reson., 2010, 203, 1-10. [DOI: 10.1016/j.jmr.2009.11.015]

101) Using NMR Solvent Relaxation to Investigate Metalloenzyme-Ligand Binding Interactions
Ivanhoe K. H. Leung, Emily Flashman, Kar Kheng Yeoh, Christopher J. Schofield and Timothy D. W. Claridge, J. Med. Chem., 2010, 53, 867-875. [DOI: 10.1021/jm901537q]

2009

100) Sulfate anion templated synthesis of a triply interlocked capsule
Yitong Li,  Kathleen M. Mullen, Tim Claridge, Paulo J. Costa, Vitor Felix, and Paul D. Beer, Chem. Comm., 2009, 7134-7136 [DOI: 10.1039/ b915548a]

99) Saturation Transfer Difference NMR reveals functionally essential kinetic differences for a sugar binding repressor protein
Ignacio Pérez-Victoria, Sebastian Kemper, Mitul K. Patel, John Edwards, James C. Errey, Lucia F. Primavesi, Matthew J. Paul, Timothy D. W. Claridge, and Benjamin G. Davis, Chem. Comm., 2009, 5862-5864 [DOI: 10.1039/b913489a]

98) A C-linked Glycomimetic in the Gas Phase and in Solution: Synthesis and Conformation of the Disaccharide Mana(1,6)-C-ManaOPh.
Ludovic Drouin, E. Cristina Stanca-Kaposta, Priptal Saundh, Antony J. Fairbanks, Sebastian Kemper, Timothy D. W. Claridge, and John P. Simons, Chem. Eur. J., 2009, 15, 4057-4069. [DOI: 10.1002/chem.200802179]

97) Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans- Carboxymethylproline.
Refaat B. Hamed, Edward T. Batchelar, Jasmin Mecinović, Timothy D. W. Claridge and Christopher J. Schofield, ChemBioChem, 2009, 10, 246-250 [DOI: 10.1002/cbic.200800652]

96) Anatomy of a Simple Acyl Enzyme Intermediate in Enzyme Catalysis - Combined Biophysical and Modelling Studies on Ornithine Acetyl Transferase
Aman Iqbal, Ian. J. Clifton, Maria Bagonis, Nadia J. Kershaw, Carmen Domene, Timothy D. W. Claridge, Christopher W. Wharton & Christopher. J. Schofield, J. Am. Chem. Soc, 2009, 131, 749-757. [DOI: 10.1021/ja807215u].

2008

 95) Highly (E)-Selective Wadsworth-Emmons Reactions Promoted by Methylmagnesium Bromide
Timothy D. W. Claridge, Stephen G. Davies, James A. Lee, Rebecca L. Nicholson, Paul M. Roberts, Angela J. Russell, Andrew D. Smith, and Steven M. Toms, Org.Lett, 2008, 10, 5437-5440. [DOI: 10.1021/ol802212e]

 94) “Pure by NMR”?
Timothy D. W. Claridge, Stephen G. Davies, Mario E. C. Polywka, Paul M. Roberts, Angela J. Russell, Edward D. Savory, and Andrew D. Smith, Org.Lett, 2008, 10, 5433-5436. [DOI: 10.1021/ol802211p]

 93) Thioester Hydrolysis and C-C Bond Formation by the Crotonase Superfamily Enzyme Carboxymethylproline Synthase
Edward T. Batchelar, Refaat B. Hamed, Christian Ducho, Timothy D. W. Claridge, Mariola J. Edelmann, Benedikt Kessler and Christopher J. Schofield, Angew. Chem. Int. Ed. Engl., 2008, 47, 9322-9325.[ DOI: 10.1002/anie.200803906]

 92) A Two-Directional Approach to Enantiopure 1,4-Difluoro- Cyclohexenes: Synthesis of Difluorinated Cyclitol Analogues
Sophie Purser, Timothy D. W. Claridge, Barbara Odell, Peter R. Moore, and Véronique Gouverneur, Org. Lett., 2008, 10, 4263-4266.  [DOI: 10.1021/ol8017402]

 91) Ammonium-directed dihydroxylation of 3-aminocyclohex-1-enes: development of a metal-free dihydroxylation protocol
Caroline Aciro, Timothy D. W. Claridge, Stephen G. Davies, Paul M. Roberts, Angela J. Russell and James E. Thomson, Org. Biomol. Chem., 2008, 6, 3751-3761, [DOI: 10.1039/b808811j]

 90) Synthesis and Conformational Analysis of Cyclic Analogues of Inverse γ-Turns
Morakot Kaewpet, Barbara Odell, Michael A. King, Biswadip Banerji, Christopher J. Schofield  and Timothy D. W. Claridge, Org. Biomol. Chem., 2008, 6, 3476-3485,   [DOI: 10.1039/b808954j]

 89) Amylose-wrapped luminescent conjugated polymers
Michael J. Frampton, Timothy D. W. Claridge, Gianluca Latini, Sergio Brovelli, Franco Cacialli and Harry L. Anderson,  Chem. Commun., 2008, 2797-2799, [DOI: 10.1039/b803335h]

 88) Secondary structural investigations into homo-oligomers of δ-2,4-cis oxetane amino acids
Timothy D. W. Claridge, Beatrice Lopez-Ortega, Sarah F. Jenkinson and George W. J. Fleet, Tet. Asymm, 2008, 19, 984-988. [DOI:10.1016/j.tetasy.2008.03.029]

 87) Oxetane amino acids: synthesis of tetrameric and hexameric carbopeptoids derived from L-ribo 4-(aminomethyl)-oxetan-2-carboxylic acid
Beatrice Lopez-Ortega, Sarah F. Jenkinson, Timothy D. W. Claridge and George W. J. Fleet, Tet. Asymm, 2008, 19, 976-983. [DOI:10.1016/j.tetasy.2008.03.030]

86) Stereospecific anti SE2’ Fluorination of Allenylsilanes: Synthesis of Enantioenriched Propargylic Fluorides
Laurence Carroll, Samantha McCullough, Tom Rees, Timothy D. W. Claridge and Véronique Gouverneur, Org. Biomol. Chem, 2008, 6, 1731-1733. [ DOI: 10.1039/b803888k]

 85) From Disulfide- to Thioether-Linked Glycoproteins
Gonçalo J. L. Bernardes , Elizabeth J. Grayson , Sam Thompson , Justin M. Chalker, James C. Errey , Farid El Oualid, Timothy D. W. Claridge, Benjamin G. Davis, Angew. Chem. Int. Ed. Engl., 2008, 47, 2244-2247. [DOI: 10.1002/anie.200704381 ]

84) Swarm formation in the desert locust Schistocerca gregaria: isolation and NMR analysis of the primary maternal gregarizing agent
Gabriel A. Miller, M. Saiful Islam, Timothy D. W. Claridge, Tim Dodgson and Stephen J. Simpson, J. Exptl. Biol., 2008, 211, 370-376. [DOI:10.1242/jeb.013458]

83) Self-assembly of Ligands Designed for the Building of a New Type of [2x2] Metallic Grid. Anion Encapsulation and Diffusion NMR Spectroscopy.
Blanca Manzano, Félix Jalón, Isabel Ortiz, M. Laura Soriano, Felipe Gomez de la Torre, José Elguero, Miguel Maestro, Kurt Mereiter, Tim D. W. Claridge, Inorganic Chemistry, 2008,  47,  413-428. [DOI: 10.1021/ic701117a]

2007

82) Solid-Phase Synthesis of Oligo(Phenylene Ethynylene) Rotaxanes.
Heather W. Daniell, Eric J. F. Klotz, Barbara Odell, Tim D. W. Claridge and Harry L. Anderson, Angew. Chem. Int. Ed. Engl., 2007, 46, 6845-6848.

81) Formation of a chiral center and pyramidal inversion at the single molecule level.
Seong-Ho Shin, Mackay B. Steffensen, Tim D. W. Claridge and Hagan Bayley, Angew. Chem. Int. Ed. Engl., 2007, 46, 7412-7416

80) Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.
Vukani Eliya Madikane, Sanjib Bhakta, Angela J. Russell, William E. Campbell, Timothy D. W. Claridge, B. Gay Elisha, Stephen G. Davies, Peter Smith and Edith Sim, Biooorg. Med. Chem., 2007, 15, 3579-3586.

79) Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer—removal of glycosidase inhibition.
David J. Hotchkiss, Atsushi Kato, Barbara Odell, Timothy D. W. Claridge and George W. J. Fleet, Tet. Asymm., 2007, 18, 500–512.

78) Metal-driven ligand assembly in the synthesis of cyclodextrin [2] and [3]rotaxanes
Andrew G. Cheetham, Timothy D. W. Claridge and Harry L. Anderson, Org. Biomol. Chem., 2007, 5, 457-462.

2006

77) Homo and hetero-[3]rotaxanes with two π-systems clasped in a single macrocycle
E. J. F. Klotz, T. D. W. Claridge, and H. L. Anderson, J. Am. Chem. Soc., 2006, 128, 15374-15375.

76) Sequential Desymmetrization-Fluorination: Enantioselective Synthesis of Fluorinated Cyclitols
Sophie Purser , Barbara Odell, Timothy D. W. Claridge, Peter R. Moore, Véronique Gouverneur, Chem. Eur. J., 2006, 12, 9176-9185.

75) Endohexosaminidase M: Exploring and Exploiting Enzyme Substrate Specificity
Thomas W. D. F. Rising, Timothy D. W. Claridge, James W. B. Moir, and Antony J. Fairbanks, Chem. BioChem., 2006, 7, 1177-1180.

74) Synthesis of N-glycan oxazolines: donors for endohexosaminidase catalysed glycosylation
Thomas W. D. F. Rising, Timothy D. W. Claridge, Nicola Davies, David P. Gamblin, James W. B. Moir and Antony J. Fairbanks, Carb. Res., 2006, 341, 1574-1596.

73) Enzymatic Synthesis and Photoswitchable Enzymatic Cleavage of a Peptide-Linked Rotaxane
Andrew G. Cheetham, Michael G. Hutchings, Tim D. W. Claridge, Harry L. Anderson, Angew. Chem. Int. Ed. Engl., 2006, 45, 1596-1599. 

2005

72) On the synthesis of pyrinodemin A. Part 1: The location of the olefin
Stuart P. Romeril, Victor Lee, Jack E. Baldwin and Timothy D. W. Claridge, Tetrahedron, 2005, 61, 1127-1140.

 71) The synthesis of oligomers of oxetane-based dipeptide isosteres derived from L-rhamnose or D-xylose.
Stephen W. Johnson, Sarah F. Jenkinson (née Barker), Donald Angus, Ignacio Pérez-Victoria, Timothy D. W. Claridge, George W. J. Fleet and John H. Jones, J. Peptide Sci., 2005, 11, 303–318.

 70) Helix-forming carbohydrate amino acids
Timothy D. W. Claridge, Daniel D. Long, Christopher M. Baker, Barbara Odell, Guy H. Grant, Alison A. Edwards, George E. Tranter, George W. J. Fleet and Martin D. Smith, J. Org. Chem. 2005, 70, 2082-2090

 69) Synthesis, structure and dynamics of methoxynaphthalene-substituted phospha-ruthenocenes and –ferrocenes
Duncan Carmichael, Louis Ricard, Nicolas Seeboth, John M. Brown, Timothy D. W. Claridge and Barbara Odell, Dalton Transactions, 2005, 12, 2173 – 2181.

68) Conformational studies of oligomeric oxetane-based dipeptide isosteres derived from L-rhamnose or D-xylose
S. W. Johnson, S. F. Jenkinson (née Barker), I. Pérez-Victoria, A. A. Edwards, T. D. W. Claridge, G. E. Tranter, G. W. J. Fleet and J. H. Jones, J. Peptide Sci., 2005, 11, 517-524.

67) Structural investigations of a lead(IV) tetraacetate-pyridine complex
J. E. H. Buston, T. D. W. Claridge, S. J. Heyes, M. A. Leech, M. G. Moloney, K. Prout and M. Stevenson, Dalton Trans., 2005, 3195-3203.

66) Hypoxia-inducible factor prolyl hydroxylase has a high affinity for ferrous iron and 2-oxoglutarate
Luke A. McNeill, Emily Flashman, Matthew R.G. Buck, Kirsty S. Hewitson, Ian J. Clifton, Gunnar Jeschke, Timothy D. W. Claridge, Dominic Ehrismann, Neil J. Oldham and Christopher J. Schofield. Mol. BioSyst., 2005, 1, 321–324.

2004

65) An unsaturated peptidomimetic assembly derived from a carbohydrate.
Y  -K. Chung, T. D. W. Claridge, G. W.J. Fleet, S. W. Johnson, J. H. Jones, K. W. Lumbard, and A. V. Stachulski, J. Peptide Sci., 2004, 10, 1-7.

64)  Thermal and palladium catalyzed pericyclic rearrangements of a pentaene ester.
Sebastien Bruckner, Jack E. Baldwin, Robert M. Adlington, Tim D. W. Claridge and Barbara Odell, Tetrahedron, 2004, 60, 2785-2788.

63) Conformationally restricted arene intermediates in the intermolecular Heck arylation of vinylarenes.
King Kuok (Mimi) Hii, Timothy D. W. Claridge, Ralf Giernoth and John M. Brown, Adv. Synth. Catal., 2004, 346, 983-988

2003

62) Biomimetic synthesis of the crispatene core.
J. E. Moses, J. E. Baldwin, R. Marquez, R. M. Adlington, T. D. W. Claridge, B. Odell, Org. Lett, 2003, 5, 661-663.

61) Nitrogen inversion as a diastereomeric relay in azasugar synthesis: the first synthesis of Adenophorine
M. A. T. Maughan, I. G. Davies, T. D. W. Claridge, S. Courtney, P. Hay and B. G. Davis, Angew. Chem. Int. Ed. Engl., 2003, 42, 3788-3792.

60) Investigations into the absolute stereochemistry of the marine sponge alkaloid pyrinodemin A
S. P. Romeril, V. Lee, J. E.Baldwin, T. D. W. Claridge and B. Odell, Tetrahedron Lett., 2003, 44, 7757-7761.

59) Enhanced 13C resolution in semi-selective HMBC: a band-selective, constant-time HMBC for complex organic structure elucidation by NMR.
T. D. W. Claridge and I. Pérez-Victoria, Org. Biomol. Chem., 2003, 1, 3632-3634.

58) Bend ribbon-forming tetrahydrofuran amino acids.
M. D. Smith, T. D. W. Claridge, M. S. P. Sansom and G. W. J. Fleet., Org. Biomol. Chem., 2003, 1, 3647-3655.

2002

57) Hypoxia-inducible factor asparaginyl hudroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803.
L. A. McNeill, K. S. Hewitson, T. D. Claridge, J. F. Seibel, L. E. Horsfall and C. J. Schofield, Biochem. J., 2002, 367, 571-575.

56) Unidirectional Photoinduced Shuttling in a Rotaxane with a Symmetric Stilbene Dumbbell
Carol A. Stanier, Sara J. Alderman, Tim D.W. Claridge and Harry L. Anderson, Angew. Chem. Int. Ed. Engl., 2002, 41, 1769-1772.

55) Structural basis for the recognition of hydroxyproline in HIF-1alpha by pVHL
Wai-Ching Hon, Michael I. Wilson, Karl Harlos, Timothy D. W. Claridge, Christopher J. Schofield, Christopher W. Pugh, Patrick H. Maxwell, Peter J. Ratcliffe, David I. Stuart & E. Yvonne Jones, Nature, 2002, 417, 975-978.

54) Synthesis of a possible structure of pyrinodemin A.
S. P. Romeril, V. Lee, T. D. W. Claridge and J. E. Baldwin, Tetrahedron Lett., 2002, 43, 327-329.

2001

53) The Intermolecular Asymmetric Heck Reaction: Mechanistic and Computational Studies
K. K. (Mimi) Hii, Timothy D. W. Claridge, John M. Brown, Andrew Smith, and Robert J. Deeth, Helvetica Chimica Acta, 2001, 84, 3043-3056.

52) Evidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis.
R. W. D. Welford, J. J. Turnbull, T. D. W. Claridge, A. G. Prescott and C. J. Schofield, Chem. Commun., 2001, 1828-1829.

51) Studies on Phytanoyl-CoA 2-hydroxylase and synthesis of Phytanoyl-Coenzyme A.
N. J. Kershaw, M. Mukherji, C. H. MacKinnon, T. D. W. Claridge, B. Odell, A. S. Wierzbicki, M. D. Lloyd and C. J. Schofield, Bioorg. Med. Chem. Lett., 2001, 11, 2545-2548.

50) Regioselective biotransformations of the dinitrile compounds 2-, 3- and 4-(cyanomethyl) benzonitrile by the soil bacterium Rhodococcus rhodochrous LL100-21.
M. R. Dadd, T. D. W. Claridge, R. Walton, A. J. Pettman, and C. J. Knowles, Enzyme Microb. Technol., 2001, 29, 20-27.

49) 10-Helical conformations in oxetane beta-amino acid hexamers.
Timothy D. W. Claridge, Jonathan M. Goodman, Andres Moreno, Donald Angus, Sarah F. Barker, Claude Taillefumier, Mark P. Watterson, and George W. J. Fleet, Tetrahedron. Lett., 2001, 42, 4251-4255.

48) cis- and trans- 3-Azido-Oxetane-2-Carboxylate Scaffolds: Hexamers of Oxetane cis-beta-Amino Acids.
Sarah F. Barker, Donald Angus, Claude Taillefumier, Michael R. Probert, David J. Watkin, Mark P. Watterson, Timothy D. W. Claridge, Natasha L. Hungerford and George W. J. Fleet, Tetrahedron. Lett., 2001, 42, 4247-4250.

47) Studies toward the total synthesis of the cytotoxic sponge alkaloid Pyrinodemin A.
J. E. Baldwin, S. P. Romeril, V. Lee and T. D. W. Claridge, Organic Lett., 2001, 3, 1145-1148.

46) Rotaxane-encapsulation enhances the stability of an azo dye, in solution and when bonded to cellulose.
Michael R. Craig, Michael G. Hutchings, Tim D. W. Claridge, and Harry L. Anderson, Angew. Chem. Int. Ed. Engl., 2001, 40, 1071-1074.

45) Biotransformation of benzonitrile to benzohydroxamic acid by Rhodococcus rhodochrous in the presence of hydroxylamine.
M. R. Dadd, T. D. W. Claridge, A. J. Pettman and C. J. Knowles, Biotech. Lett., 2001, 23, 221-225

44) 207Pb NMR chemical shifts of lead tetracarboxylates.
Jonathan. E. Buston, Tim D. W. Claridge, Stephen J. Heyes, Jeremy L. Bretherton, Mark G. Moloney and Maya Stevenson, Magn. Reson. Chem., 2001, 39, 68-76.

2000

43) Oxidative degradation of bilirubin produces vasoactive compounds.
Kamil R. Kranc, Gail J. Pyne, Limei Tao, Tim D. W. Claridge, David A. Harris, Thomas A. D. Cadoux-Hudson, Jonathan J. Turnbull, Christopher J. Schofield and Joseph F. Clark, Eur. J. Biochem. 2000, 267, 7094-7101.

42) Tetrahydrofuran amino acids: Secondary structure in tetrameric and octameric carbopeptoids derived from a D-allo-5-(aminomethyl)-tetrahydrofuran-2-carboxylic acid.
N. L. Hungerford, T. D. W. Claridge, M. P. Watterson, R. T. Aplin, A. Moreno and G. W. J. Fleet, J. Chem. Soc., Perkin Trans.1, 2000, 3666-3679.

41) Tetrahydrofuran amino acids- versatile building blocks for unnatural biopolymers: lack of secondary structure in oligomeric carbopeptoids derived from a D-galacto-5-(aminomethyl) tetrahydrofuran-2-carboxylic acid.
D E. A. Brittain, M. P. Watterson, T. D. W. Claridge. M. D. Smith and G. W. J. Fleet, J. Chem. Soc., Perkin Trans.1, 2000, 3655-3665.

40) Reaction of clavams with elastase reveals a general method for inhibiting 'serine' enzymes.
R. C. Wilmouth, Y-H. Li, P. A. Wright, T. D. W. Claridge, R. T. Aplin and C. J. Schofield, Tetrahedron, 2000, 56, 5729-5733.

39) Synthesis and crystal structure of a cumulenic quinoidal porphyrin dimer with strong electronic absorption in the infrared.
I. M. Blake, L. H. Rees, T. D. W. Claridge and H. L. Anderson, Angew. Chem. Int. Ed. Engl., 2000, 39, 1818-1821

1999

38) Synthesis of a cyclodextrin azo dye [3]rotaxane as a single isomer.
M. R. Craig, T. D. W. Claridge, M. G. Hutchings and H. L. Anderson, Chem. Commun., 1999, 1537-1538.

37) Studies on the biomimetic synthesis of the manzamine alkaloids.
J. E. Baldwin, T. D. W. Claridge, A. J. Culshaw, F. A. Heupel, V. Lee, D. R. Spring and R. C. Whitehead, Chem. Eur. J., 1999, 5, 3154-3161.

36) Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.
R. C. Wilmouth, S. Kassamally, N. J. Westwood, R. J. Sheppard, T. D. W. Claridge, R. T. Aplin, P. A. Wright, G. J. Pritchard and C. J. Schofield, Biochemistry, 1999, 38, 7989-7998.

35) Absence of secondary structure in a carbopeptoid teramer of a trans-5-aminomethyl-tetrahydrofuran-2-carboxylate.
M. D. Smith, D. D. Long, A. Martin, D. G. Marquess, T. D. W. Claridge, and G. W. J. Fleet, Tetrahedron Lett., 1999, 40, 2191-2194.

34) From sequencamers to foldamers? Tetrameric furanose carbopeptoids from cis- and trans-5-aminomethyl-tetrahydrofuran-2-carboxylates.
D. D. Long, N. L. Hungerford, M. D. Smith, D. E. A. Brittain, D. G. Marquess, T. D. W. Claridge, and G. W. J. Fleet, Tetrahedron Lett., 1999, 40, 2195-2198.

33) An octameric carbopeptoid; secondary structure in octameric ans tetrameric 5-aminomethyl-tetrahydrofuran-2-carboxylates.
T. D. W. Claridge, D. D. Long, N. L. Hungerford, R. T. Aplin, M. D. Smith, D. G. Marquess, and G. W. J. Fleet, Tetrahedron Lett., 1999, 40, 2199-2202.

1998

32) Inhibition of elastase by N-sulfonylaryl beta-lactams: Anatomy of a stable acyl-enzyme complex.
R. C. Wilmouth, N. J. Westwood, K. Anderson, W. Brownlee, T. D. W. Claridge, I. J. Clifton, G. J. Pritchard, R. T. Aplin, C. J. Schofield, Biochemistry, 1998, 37, 17506-17513.

31) A solid phase approach to oligomers of carbohydrate amino-acids: Secondary structure in a trimeric furanose carbopeptoid
D. D. Long, M. D. Smith, D. G. Marquess, T. D. W. Claridge, and G. W. J. Fleet, Tetrahedron. Lett., 1998, 39, 9293-9296.

30) Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis
J. E. Baldwin, T. D. W. Claridge, A. J. Culshaw, F. A. Heupel, V. Lee, D. R. Spring, R. C. Whitehead, R. J. Boughtflower, I. M. Mutton, and R. J. Upton. Angew. Chem. Int. Ed. Engl., 1998, 37, 2661-2663.

29) Secondary structure in oligomers of carbohydrate amino acids
M. D. Smith, T. D. W. Claridge, G. E. Tranter, M. S. P. Sansom, and G. W. J. Fleet, J. Chem. Soc., Chem. Commun., 1998, 2041-2042.

28) Synthesis of oligomers of tetrahydrofuran amino acids: furanose carbopeptoids
M. D. Smith, D. D. Long, D. G. Marquess, T. D. W. Claridge, and G. W. J. Fleet, J. Chem. Soc., Chem. Commun., 1998, 2039-2040.

27) An approach to insulated molecular wires: synthesis of water-soluble conjugated rotaxanes
S. Anderson, R. T. Aplin, T. D. W. Claridge, T. Goodson III, A. C. Maciel, G. Rumbles, J. F. Ryan and H. L. Anderson, J. Chem. Soc., Perkin Trans. 1, 1998, 2383-2397.

26) Synthesis of (2S, 3R, 4S), (2S, 3S, 4R)-Epoxyprolines and Aminohydroxyprolines.
J. K. Robinson, V. Lee, T. D. W. Claridge, J. E. Baldwin and C. J. Schofield, Tetrahedron, 1998, 54, 981-996.

25) Analysis of the conversion of δ-(L-α-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate by active-site mutants of Aspergillus nidulans isopenicillin N synthase.
C. J. Rowe, C. P. Shorrock, T. D. W. Claridge and J. D. Sutherland, Chem. & Biol., 1998, 5, 229-239.

24) 207Pb NMR Chemical Shifts of Aryllead Tricarboxylates.
J. E. H. Buston, T. D. W. Claridge, R. G. Compton and M. G. Moloney, Magn. Reson. Chem., 1998, 36, 140-144.

1997

23) Thermoelectric cooling for NMR Sample Temperature Control.
N. L. Gregory, T. D. W. Claridge and M. Leonard, J. Magn. Reson., 1997, 124, 228-231.

22) An Approach to the Manzamine Alkaloids Modelled on a Biogenetic Theory.
J. E. Baldwin, L. Bischoff, T. D. W. Claridge, F. A. Heupel, D. R. Spring and R. C. Whitehead, Tetrahedron, 1997, 53, 2271-2290.

21) 207Pb, 13C and 1H Nuclear Magnetic Resonance Studies of Lead(IV) Carboxylates in Solution.
T. D. W. Claridge, E. J. Nettleton and M. G. Moloney, Magn. Reson. Chem., 1997, 35, 159-167.

20) Synthesis of 1-Methyl-2-diphenylphosphino-3-(1’-isoquinolyl)indole; an Easily Racemised Ligand giving Insights into Catalytic Asymmetric Allylation.
T. D. W. Claridge, J. M. Long, J. M. Brown, D. Hibbs and M. B. Hursthouse, Tetrahedron, 1997, 53, 4035-4050.

19) Intermediates in the Intermolecular, Asymmetric Heck Arylation of Dihydrofurans.
K. K. Hii, T. D. W. Claridge and J. M. Brown, Angew. Chem. Int. Ed. Engl., 1997, 36, 984-987.

18) Azo-Dye Rotaxanes.
S. Anderson, T. D. W. Claridge and H. L. Anderson, Angew. Chem. Int. Ed. Engl., 1997, 36, 1310-1313.

17) Studies on the reactivity of azetidin-2-ones in phosphate buffer.
N. J. Westwood, C. J. Schofield and T. D. W. Claridge, J. Chem. Soc, Perkin Trans. 1, 1997, 2725-2729.

16) Reversible acylation of Elastase by γ-lactam analogues of β-lactam inhibitors.
N. J. Westwood, T. D. W. Claridge, P. N. Edwards and C. J. Schofield, Bioorg. Med. Chem. Lett., 1997, 7, 2973-2978.

1996

15) Determination of the Stereochemistry of Four Spirodiastereoisomers by One- and Two-Dimensional NOE studies.
A. Moreno, A. Diaz-Ortiz, E. Diez-Barra, A. de la Hoz, F. Langa, P. Prieto and T. D. W. Claridge, Magn. Reson. Chem., 1996, 34, 52-58.

14) Synthesis and Analysis of Leu-Enkephalin Analogues Containing Reverse Turn Peptidomimetics.
T. D. W. Claridge, C. Hulme, R. J. Kelly, V. Lee, I. A. Nash, and C. J. Schofield, Biorg. Med. Chem. Lett., 1996, 6, 485-490.

13) Inhibition of Human Leukocyte and Porcine Pancreatic Elastase by Homologues of Bovine Pancreatic Trypsin Inhibitor.
J. A. E. Kraunsoe, T. D. W. Claridge and G. Lowe, Biochemistry, 1996, 35, 9090-9096.

12) Structure and Properties of TentaGel Resin Beads: Implications for Combinatorial Library Chemistry.
R. Quarrell, T. D. W. Claridge, G. W. Weaver and G. Lowe, Molecular Diversity, 1996, 1, 223-232.

11) A Biomimetic Approach to the Manzamine Alkaloids.
J. E. Baldwin, T. D. W. Claridge, A. J. Culshaw, F. A. Heupel, S. Smrckova, and R. C. Whitehead, Tetrahedron Lett., 1996, 37, 6919-6922.

1995

10) Structure and Dynamics of Intermediates in Asymmetric Hydrogenation by Rhodium Complexes of (2-Methoxyphenyl)-P-phenyl-P-(2’-diphenylphosphino)ethylphosphine.
J. A. Ramsden, T. D. W. Claridge and J. M. Brown, J. Chem. Soc., Chem. Commun., 1995, 2469-2471.

9) Synthesis and Chemistry of a New P-N Chelating Ligand; (R) and (S)-6-(2’-Diphenylphosphino-1’-napthyl)phenanthridine.
J-M. Valk, T. D.W. Claridge, J. M. Brown, D. Hibbs and M. B. Hursthouse, Tetrahedron: Asymmetry, 1995, 6, 2597-2610.

8) Observation of intermolecular ligand exchange in lead(IV) carboxylates by 1- and 2-D 207Pb NMR spectroscopy.
J. E. H. Buston, T. D. W. Claridge and M. G. Moloney, J. Chem. Soc., Perkin Trans. 2, 1995, 4, 639-641.

 1994

7) Equipment for selective excitation in NMR spectroscopy: enhanced techniques for radio-frequency modulation and digital pulse-shape generation.
N. L. Gregory, T. D. W. Claridge and A. E. Derome, Meas. Sci. Technol., 1994, 5, 1359-1365.

6) A biomimetic approach to the Manzamine Alkaloids; model studies.
J. E. Baldwin, T. D. W. Claridge, F. A. Heupel and R. C. Whitehead, Tetrahedron Lett., 1994, 35, 7829-7832.

5) Comments on the use of a dichromophoric circular dichroism assay for the identification of β-turns in peptides.
J. E. Baldwin, T. D. W. Claridge, C. Hulme, A. Rodger and C. J. Schofield, Int. J. Peptide Protein Res., 1994, 43, 180-183.

1993

4) Revised structures for Tü 1718B and Valclavam
J. E. Baldwin, T. D. W. Claridge, K-C. Goh, J. W. Keeping and C. J. Schofield, Tetrahedron Lett., 1993, 34, 5645-5648.

3) The molecular structure of Dendrotoxin homologues determined by molecular modeling methods and their comparison with the crystal and the 2D-NMR structures.
A. Opalko, T. Claridge, R. Crossley, A. E. Derome, and P. Swaminathan. J. Cell. Biochem., 1993, s17c, 225.

1991

2) Direct observation of a tetrahedral boronic acid-β-lactamase complex using 11B NMR spectroscopy.
J. E. Baldwin, T. D. W. Claridge, A. E. Derome, B. D. Smith, M. Twyman and S. G. Waley. J. Chem. Soc., Chem. Commun., 1991, 573-574.

1) 11B NMR studies of an aryl boronic acid bound to chymotrypsin and subtilisin.
J. E. Baldwin, T. D. W. Claridge, A. E. Derome, C. J. Schofield and B. D. Smith, Bioorg. Med. Chem. Lett, 1991, 1, 9-12.